Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic
Timothy A. Chan,Mark Yarchoan,Elizabeth M. Jaffee,Charles Swanton,Sergio A. Quezada,Albrecht Stenzinger,Solange Peters +6 more
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TLDR
TMB, in concert with PD-L1 expression, has been demonstrated to be a useful biomarker for ICB selection across some cancer types; however, further prospective validation studies are required.About:
This article is published in Annals of Oncology.The article was published on 2019-01-01 and is currently open access. It has received 1490 citations till now. The article focuses on the topics: Biomarker (medicine).read more
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Immunotherapy in colorectal cancer: rationale, challenges and potential.
Karuna Ganesh,Zsofia K. Stadler,Andrea Cercek,Robin B. Mendelsohn,Jinru Shia,Neil H. Segal,Luis A. Diaz +6 more
TL;DR: Clinical development of immune checkpoint inhibition in CRC leading to regulatory approvals for the treatment of dMMR–MSI-H CRC is reviewed and new advances in expanding the efficacy of immunotherapy to early-stage CRC and CRC that is mismatch-repair-proficient and has low microsatellite instability (pMMR- MSI-L) are focused on.
Journal ArticleDOI
High tumor mutation burden fails to predict immune checkpoint blockade response across all cancer types.
Daniel J. McGrail,Patrick G. Pilie,Naim U. Rashid,Leonie Voorwerk,Maarten Slagter,Marleen Kok,Eric Jonasch,Mustafa Khasraw,Amy B. Heimberger,Bora Lim,NT Ueno,Jennifer K. Litton,Renata Ferrarotto,Jeffrey T. Chang,S. L. Moulder,Sy Lin +15 more
TL;DR: In this article, the authors compared approaches to determine TMB and identify the correlation between predicted neoantigen load and CD8 T cells, and found that TMB-H tumors exhibited a 39.8% ORR to ICB [95% confidence interval (CI) 34.9-44.8], which was significantly higher than that observed in low TMB (TMB-L) tumors.
Journal ArticleDOI
PD-L1 as a biomarker of response to immune-checkpoint inhibitors
Deborah B. Doroshow,Sheena Bhalla,Mary Beth Beasley,Lynette M. Sholl,Keith M. Kerr,Sacha Gnjatic,Ignacio I. Wistuba,David L. Rimm,Ming-Sound Tsao,Fred R. Hirsch +9 more
TL;DR: In this paper, the authors describe the current role of PD-L1 immunohistochemistry assays used to inform the selection of patients to receive antiPD-1 or anti-PD-L 1 antibodies, discuss the various technical and clinical challenges associated with these assays, including regulatory issues, and provide some perspective on how to optimize PDL1 as a selection biomarker for the future treatment of patients with solid tumours.
Journal ArticleDOI
Advances in immunotherapy for hepatocellular carcinoma
TL;DR: A recent review as mentioned in this paper provides up-to-date information on the best use of currently available immunotherapies in HCC and the therapeutic strategies under development, including the discovery and validation of predictive biomarkers, advancing treatment to earlier stages of the disease, applying the treatment to patients with liver dysfunction and the discovery of more effective combinatorial or sequential approaches.
Journal ArticleDOI
Advances in cancer immunotherapy 2019 – latest trends
Stephan Kruger,Stephan Kruger,Matthias Ilmer,Matthias Ilmer,Sebastian Kobold,Bruno L. Cadilha,Stefan Endres,Steffen Ormanns,Gesa Schuebbe,Bernhard W. Renz,Bernhard W. Renz,Jan G. D’Haese,Hans Anton Schloesser,Volker Heinemann,Volker Heinemann,Marion Subklewe,Marion Subklewe,Stefan Boeck,Stefan Boeck,Jens Werner,Michael von Bergwelt-Baildon +20 more
TL;DR: This review summarizes seminal findings from clinical and translational studies recently presented or published at important meetings or in top-tier journals, respectively, regarding cellular immunotherapy and checkpoint blockade.
References
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Signatures of mutational processes in human cancer
Ludmil B. Alexandrov,Serena Nik-Zainal,Serena Nik-Zainal,David C. Wedge,Samuel Aparicio,Sam Behjati,Sam Behjati,Andrew V. Biankin,Graham R. Bignell,Niccolo Bolli,Niccolo Bolli,Åke Borg,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Sandrine Boyault,Birgit Burkhardt,Adam Butler,Carlos Caldas,Helen Davies,Christine Desmedt,Roland Eils,Jorunn E. Eyfjord,John A. Foekens,Mel Greaves,Fumie Hosoda,Barbara Hutter,Tomislav Ilicic,Sandrine Imbeaud,Sandrine Imbeaud,Marcin Imielinsk,Natalie Jäger,David T. W. Jones,David T. Jones,Stian Knappskog,Stian Knappskog,Marcel Kool,Sunil R. Lakhani,Carlos López-Otín,Sancha Martin,Nikhil C. Munshi,Nikhil C. Munshi,Hiromi Nakamura,Paul A. Northcott,Marina Pajic,Elli Papaemmanuil,Angelo Paradiso,John V. Pearson,Xose S. Puente,Keiran Raine,Manasa Ramakrishna,Andrea L. Richardson,Andrea L. Richardson,Julia Richter,Philip Rosenstiel,Matthias Schlesner,Ton N. Schumacher,Paul N. Span,Jon W. Teague,Yasushi Totoki,Andrew Tutt,Rafael Valdés-Mas,Marit M. van Buuren,Laura van ’t Veer,Anne Vincent-Salomon,Nicola Waddell,Lucy R. Yates,Icgc PedBrain,Jessica Zucman-Rossi,Jessica Zucman-Rossi,P. Andrew Futreal,Ultan McDermott,Peter Lichter,Matthew Meyerson,Matthew Meyerson,Sean M. Grimmond,Reiner Siebert,Elias Campo,Tatsuhiro Shibata,Stefan M. Pfister,Stefan M. Pfister,Peter J. Campbell,Peter J. Campbell,Peter J. Campbell,Michael R. Stratton,Michael R. Stratton +84 more
TL;DR: It is shown that hypermutation localized to small genomic regions, ‘kataegis’, is found in many cancer types, and this results reveal the diversity of mutational processes underlying the development of cancer.
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