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Journal ArticleDOI

Developmental pathways to functional brain networks: emerging principles

Vinod Menon
- 01 Dec 2013 - 
- Vol. 17, Iss: 12, pp 627-640
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TLDR
How complementary methods for probing functional connectivity are providing unique insights into the emergence and maturation of distinct functional networks from childhood to adulthood is described.
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This article is published in Trends in Cognitive Sciences.The article was published on 2013-12-01. It has received 267 citations till now. The article focuses on the topics: Brain mapping.

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The hubs of the human connectome are generally implicated in the anatomy of brain disorders

TL;DR: Using network analysis of DTI data from healthy volunteers, and meta-analyses of published MRI studies in 26 brain disorders, Crossley et al. show that lesions across disorders tend to be concentrated at hubs.
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Unraveling the Miswired Connectome: A Developmental Perspective

TL;DR: The most common mental illnesses can be conceptualized as developmental disorders of neural interactions within the connectome, or developmental miswiring as mentioned in this paper, and the recent maturation of pediatric in vivo brain imaging is bringing the identification of clinically meaningful brain-based biomarkers of developmental disorders within reach.
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An Integrative Model of the Maturation of Cognitive Control

TL;DR: In this paper, a model of the brain basis of the development of cognitive control is proposed, which provides a novel understanding of the adolescent period as an adaptive period of heightened experience-seeking.
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The Contribution of Network Organization and Integration to the Development of Cognitive Control.

TL;DR: The results indicate that network organization is stable throughout adolescence, and support a novel, two-stage model of neural development, in which networks stabilize prior to adolescence and subsequently increase their integration to support the cross-domain incorporation of information processing critical for mature cognitive control.
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The Default Mode Network in Autism

TL;DR: It is suggested that aberrancies in key nodes of the DMN and their dynamic functional interactions contribute to atypical integration of information about the self in relation to 'other', as well as impairments in the ability to flexibly attend to socially relevant stimuli.
References
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A default mode of brain function.

TL;DR: A baseline state of the normal adult human brain in terms of the brain oxygen extraction fraction or OEF is identified, suggesting the existence of an organized, baseline default mode of brain function that is suspended during specific goal-directed behaviors.
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Emotion Circuits in the Brain

TL;DR: The field of neuroscience has, after a long period of looking the other way, again embraced emotion as an important research area, and much of the progress has come from studies of fear, and especially fear conditioning as mentioned in this paper.
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Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging.

TL;DR: Recent studies examining spontaneous fluctuations in the blood oxygen level dependent (BOLD) signal of functional magnetic resonance imaging as a potentially important and revealing manifestation of spontaneous neuronal activity are reviewed.
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Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive Control

TL;DR: Two distinct networks typically coactivated during functional MRI tasks are identified, anchored by dorsal anterior cingulate and orbital frontoinsular cortices with robust connectivity to subcortical and limbic structures, and an “executive-control network” that links dorsolateral frontal and parietal neocortices.
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Functional connectivity in the resting brain: A network analysis of the default mode hypothesis

TL;DR: This study constitutes, to the knowledge, the first resting-state connectivity analysis of the default mode and provides the most compelling evidence to date for the existence of a cohesive default mode network.
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