Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex
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...Genome-wide epigenetic analyses in a cell type-specific manner are crucially needed in addiction researc...
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...Cheung et al. (2010) profiled histone 3 lysine 4 trimethylation (H3K4me3) across development in neuronal and nonneuronal cells of the human prefrontal cortex of 11 individuals ranging in age from 0.5 to 69 postnatal years....
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"Developmental regulation and indivi..." refers background in this paper
...3) allowing up to one mismatch (29) to map all sequence reads to the gender appropriate human genome HG18, and 67–87% of the reads in the neuronal samples mapped to one unique location in the genome....
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"Developmental regulation and indivi..." refers methods in this paper
...We used the DAVID 2008 web-server (31)for detecting enriched GO (Gene...
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"Developmental regulation and indivi..." refers methods in this paper
...We also included three publicly available H3K4me3 ChIP-Seq datasets as control: CD4 T lymphocytes (11), and the K562 [chronic myelogenous leukemia (CML)] and GM12878 (lymphoblastoid) cell lines (12)....
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...Additional H3K4me3 ChIP-Seq data were obtained for CD4 T cells (11), and for two cell lines (GM12878 and K562) from the UCSC ENCODE webpage (12)....
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