Diagnosis of Lung Cancer in Small Biopsies and Cytology: Implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification
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Cites background or methods from "Diagnosis of Lung Cancer in Small B..."
..., TTF-1 and P40 or P63).(11,21) Thus a simple panel of TTF-1 and p40 may be able to classify most NSCC NOS cases....
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...• Nuclear atypia is absent or inconspicuous • Septal widening with sclerosis/elastosis is common, particularly in nonmucinous adenocarcinoma in situ aModified from the articles by Travis et al.1,7,11 Copyright © 2015 by the International Association for the Study of Lung Cancer 1249Copyright © 2015 by the International Association for the Study of Lung Cancer primary lung adenocarcinomas that are lepidic predominant invasive adenocarcinoma should be called “adenocarcinoma, lepidic subtype” or “lepidic adenocarcinoma” with mention of the percentage of the lepidic component and listing of each of the other patterns present with their estimated percentage....
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...In relation to squamous differentiation, P40 is reported as the most specific and sensitive squamous marker.18–20 Other previously recommended antibodies include cytokeratin 5/6 and P63....
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...Modified from the articles by Travis et al.(1,7,11) Metastasis of colorectal cancer should be carefully excluded with judicious immunohistochemical stains and clinical evaluation....
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...In 2011, a new IASLC/ATS/ERS classification of lung adenocarcinoma proposed significant changes to the 2004 WHO classification for resected tumors including (1) discontinuing the terms bronchioloalveolar carcinoma (BAC) and mixed subtype adenocarcinoma; (2) the addition of AIS as a preinvasive lesion to join atypical adenomatous hyperplasia; (3) addition of MIA, (4) classification of invasive adenocarcinomas according to the predominant subtype after comprehensive histologic subtyping by semiquantitatively estimating the percentage of the various subtypes present in 5% increments; (5) use of the term “lepidic” for a noninvasive component (previously classified as BAC) present as part of an invasive adenocarcinoma; (6) introducing the term “invasive mucinous adenocarcinoma” for adenocarcinomas formerly classified as mucinous BAC, excluding tumors that meet criteria for AIS or MIA; (7) discontinuing the subtypes of clear cell and signet ring adenocarcinoma and recognizing these as a feature when any amount is present, however small; (8) discontinuing the term mucinous cystadenocarcinoma and including these under the category of colloid adenocarcinoma.(3,7,11,40) Subsequent to the 2011 IASLC/ATS/ERS lung adenocarcinoma classification and with the development of the 2015 WHO classification, it was decided to classify tumors formerly called large cell carcinomas that have pneumocyte marker expression (i....
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2,349 citations
Cites background from "Diagnosis of Lung Cancer in Small B..."
...In those cases of NSCLC where specific subtyping is not possible by morphology alone, a limited panel of IHC is recommended to determine the subtype [39, 40]....
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