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Diagnostic and therapeutic challenges.
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This case is submitted by Drs.Abstract:
This case is submitted by Drs. Francisco J. Ascaso, Maria Rojo, and Enrique Minguez from the Department of Ophthalmology, “Lozano Blesa” University Clinic Hospital, Zaragoza, Spain, for the Diagnostic and Therapeutic Challenges Section of Retina; and commented by Dr. Steven M. Cohen, Clearwater, Floread more
Citations
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Clinicopathologic correlates of solitary fibrous tumors.
Fionula M. Brennan,Muhammad M. Hussain,Helen J Lewis,Daniel G. Coit,Cristina R. Antonescu,Cristina H. Hajdu,Cristina R. Ferrone,Robert S. Gold +7 more
TL;DR: In this paper, solitary fibrous tumors (SFTs) are rare fibrous neoplasms arising from the pleura and have been reported at a wide range of anatomic sites.
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Short and tall stature: a new paradigm emerges
Jeffrey Baron,Lars Sävendahl,Francesco De Luca,Andrew Dauber,Moshe Phillip,Jan M. Wit,Ola Nilsson +6 more
TL;DR: Findings point to a new conceptual framework for understanding short and tall stature that is centred not on two particular hormones but rather on the growth plate, which is the structure responsible for height gain.
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Physical and psychosocial risk factors for lateral epicondylitis: a population based case-referent study.
TL;DR: It is indicated that being a new case of tennis elbow is associated with non-neutral postures of hands and arms, use of heavy hand held tools, and high physical strain measured as a combination of forceful work, non- neutral posture of Hands and Arms, and repetition.
Journal ArticleDOI
The Expanded Spectrum of Focal Choroidal Excavation
Ron Margolis,Sri Krishna Mukkamala,Lee M. Jampol,Richard F. Spaide,Michael D. Ober,John A. Sorenson,Ronald C. Gentile,Joel A. Miller,Jerome Sherman,K. Bailey Freund +9 more
TL;DR: Focal choroidal excavation is a newly described idiopathic entity in eyes having 1 or more focal areas of choroid excavation and in some patients, there may be an association with central serous chorioretinopathy.
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Paraneoplastic and non-paraneoplastic retinopathy and optic neuropathy: Evaluation and management
Ehsan Rahimy,David Sarraf +1 more
TL;DR: The clinical features, pathogenesis, and treatment strategies for the retinal- and optic nerve-based paraneoplastic syndromes, including cancer-associated retinopathy, and the utility and interpretation of autoantibody testing are outlined.
References
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A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation☆
TL;DR: The method of classifying comorbidity provides a simple, readily applicable and valid method of estimating risk of death fromComorbid disease for use in longitudinal studies and further work in larger populations is still required to refine the approach.
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The Hospital Anxiety and Depression Scale.
A. S. Zigmond,R. P. Snaith +1 more
TL;DR: It is suggested that the introduction of the scales into general hospital practice would facilitate the large task of detection and management of emotional disorder in patients under investigation and treatment in medical and surgical departments.
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The Timed “Up & Go”: A Test of Basic Functional Mobility for Frail Elderly Persons
TL;DR: This study evaluated a modified, timed version of the “Get‐Up and Go” Test (Mathias et al, 1986) in 60 patients referred to a Geriatric Day Hospital and suggested that the timed “Up & Go’ test is a reliable and valid test for quantifying functional mobility that may also be useful in following clinical change over time.
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Mutation and Cancer: Statistical Study of Retinoblastoma
TL;DR: The hypothesis is developed that retinoblastoma is a cancer caused by two mutational events, in the dominantly inherited form, one mutation is inherited via the germinal cells and the second occurs in somatic cells.
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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Patrick H. Maxwell,Michael S. Wiesener,Gin-Wen Chang,Steven C. Clifford,Emma C. Vaux,Matthew Edward Cockman,Charles C. Wykoff,Christopher W. Pugh,Eamonn R. Maher,Peter J. Ratcliffe,Peter J. Ratcliffe +10 more
TL;DR: It is indicated that the interaction between HIF-1 and pVHL is iron dependent, and that it is necessary for the oxygen-dependent degradation of HIF α-subunits, which may underlie the angiogenic phenotype of VHL-associated tumours.