Diagnostics for SARS-CoV-2 infections.
Bhavesh D. Kevadiya,Jatin Machhi,Jonathan Herskovitz,Maxim D. Oleynikov,Wilson R. Blomberg,Neha Bajwa,Dhruvkumar Soni,Srijanee Das,Mahmudul Hasan,Milankumar Patel,Ahmed M. Senan,Santhi Gorantla,JoEllyn M McMillan,Benson J Edagwa,Robert Eisenberg,Channabasavaiah B. Gurumurthy,St Patrick Reid,Chamindie Punyadeera,Linda Chang,Howard E. Gendelman +19 more
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TLDR
A review of available and in-development diagnostic tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) including nanomaterial-based tools is presented in this paper.Abstract:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to nearly every corner of the globe, causing societal instability. The resultant coronavirus disease 2019 (COVID-19) leads to fever, sore throat, cough, chest and muscle pain, dyspnoea, confusion, anosmia, ageusia and headache. These can progress to life-threatening respiratory insufficiency, also affecting the heart, kidney, liver and nervous systems. The diagnosis of SARS-CoV-2 infection is often confused with that of influenza and seasonal upper respiratory tract viral infections. Due to available treatment strategies and required containments, rapid diagnosis is mandated. This Review brings clarity to the rapidly growing body of available and in-development diagnostic tests, including nanomaterial-based tools. It serves as a resource guide for scientists, physicians, students and the public at large.read more
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Testing at scale during the COVID-19 pandemic.
Tim R. Mercer,Marc L. Salit +1 more
TL;DR: A review of the role of testing during the COVID-19 pandemic can be found in this article, where the authors describe the changing role of the testing during this pandemic, including the use of genomic surveillance to track SARS-CoV-2 transmission, contact tracing to contain disease outbreaks and testing for the presence of the virus circulating in the environment.
Journal ArticleDOI
Advances and applications of nanophotonic biosensors
TL;DR: In this article , the authors provide an overview of the recent developments of label-free nanophotonic biosensors using evanescent-field-based sensing with plasmon resonances in metals and Mie resonance in dielectrics and highlight the prospects of achieving an improved sensor performance and added functionalities by leveraging nanostructures and on-chip and optoelectronic integration, as well as microfluidics, biochemistry and data science toolkits.
Journal ArticleDOI
Review of Current COVID-19 Diagnostics and Opportunities for Further Development
TL;DR: A comprehensive review of currently available COVID-19 diagnostics, exploring their pros and cons as well as appropriate indications are suggested in this article, where several sample-toanswer platforms, including high-throughput systems and Point of Care (PoC) assays, have been developed to increase testing capacity and decrease technical errors.
Journal ArticleDOI
Point-of-care COVID-19 diagnostics powered by lateral flow assay.
TL;DR: In this paper, the authors summarized the crucial role of rapid diagnostic tests using lateral flow assay (LFA) in targeting SARS-CoV-2-specific RNA, antibodies, antigens, and whole virus.
Journal ArticleDOI
Rapid One-Step Detection of Viral Particles Using an Aptamer-Based Thermophoretic Assay.
Jinqi Deng,Jinqi Deng,Fei Tian,Fei Tian,Chao Liu,Chao Liu,Yuan Liu,Shuai Zhao,Shuai Zhao,Ting Fu,Jiashu Sun,Jiashu Sun,Weihong Tan,Weihong Tan +13 more
TL;DR: In this article, a one-step thermophoretic approach using an aptamer and polyethylene glycol (PEG) was proposed for direct quantitative detection of viral particles.
References
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TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia.
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Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR.
Victor M. Corman,Olfert Landt,Marco Kaiser,Richard Molenkamp,Adam Meijer,Daniel K.W. Chu,Tobias Bleicker,Sebastian Brünink,Julia Schneider,Marie Luisa Schmidt,Daphne G.J.C. Mulders,Bart L. Haagmans,Bas van der Veer,Sharon van den Brink,Lisa Wijsman,Gabriel Goderski,Jean Louis Romette,Joanna Ellis,Maria Zambon,Malik Peiris,Herman Goossens,Chantal B.E.M. Reusken,Marion Koopmans,Christian Drosten +23 more
TL;DR: A validated diagnostic workflow for 2019-nCoV is presented, its design relying on close genetic relatedness of 2019- nCoV with SARS coronavirus, making use of synthetic nucleic acid technology.
Journal ArticleDOI
The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2
Alexander E. Gorbalenya,Susan C. Baker,Ralph S. Baric,Raoul J. de Groot,Christian Drosten,Anastasia A. Gulyaeva,Bart L. Haagmans,Chris Lauber,Andrey M. Leontovich,Benjamin W. Neuman,Dmitry Penzar,Stanley Perlman,Leo L.M. Poon,Dmitry V. Samborskiy,Igor A. Sidorov,Isabel Sola,John Ziebuhr +16 more
TL;DR: The independent zoonotic transmission of SARS-CoV and SARS -CoV-2 highlights the need for studying viruses at the species level to complement research focused on individual pathogenic viruses of immediate significance.
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