Journal ArticleDOI
Dibromomethane as one-carbon source in organic synthesis: a versatile methodology to prepare the cyclic and acyclic α-methylene or α-keto acid derivatives from the corresponding terminal alkenes
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TLDR
Ozonolysis of mono-substituted alkenes A-1 followed by reacting with a preheated mixture of CH2Br2-Et2NH affords α-substantituted acroleins A-2 in good yields.About:
This article is published in Tetrahedron.The article was published on 2004-05-24. It has received 40 citations till now. The article focuses on the topics: Ozonolysis & Organic synthesis.read more
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Patent
Hcv ns3 protease inhibitors
M. Katharine Holloway,Nigel J. Liverton,Steven W. Ludmerer,John A. Mccauley,David B. Olsen,Michael T. Rudd,Joseph P. Vacca,Charles J. Mcintyre +7 more
TL;DR: The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
Journal ArticleDOI
Recent Developments in General Methodologies for the Synthesis of α-Ketoamides
TL;DR: An overview of the diverse methodologies that have emerged since the 1990s up to the present regarding the synthesis of α-ketoamide compounds by palladium-catalyzed double-carbonylative amination reactions is discussed.
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Strategies and approaches for constructing 1-oxadecalins
Patent
Macrocyclic compounds as antiviral agents
Benedetta Crescenzi,Monica Donghi,Marco Ferrara,Cristina Gardelli,Steven Harper,Uwe Koch,Michael Rowley,Vincenzo Summa +7 more
TL;DR: The present invention relates to macrocyclic compounds of formula (I): wherein W, n, R1, Ra, Rb, R3, R4, M, Z, ring A and ring B are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C virus as discussed by the authors.
Journal ArticleDOI
Enantioselective Organocatalytic Approach to α-Methylene-δ-lactones and δ-Lactams
TL;DR: This methodology utilizes the Michael addition of unmodified aldehydes to ethyl 2-(diethoxyphosphoryl)acrylate as the key step affording highly enantiomerically enriched adducts, which can be transformed into the target compounds maintaining the high stereoselectivity achieved in the first step.
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Journal ArticleDOI
Comprehensive organic chemistry : the synthesis and reactions of organic compounds
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1,3-Dipolar Cycloaddition Chemistry
TL;DR: The theory of 1-3-Dipolar Cycloadditions is discussed in this article. But it does not consider higher-order cycloaddings and higher order cycloreversions.
Journal ArticleDOI
Oxidation of α,β-un saturated aldehydes
TL;DR: A variety of methods for the conversion of α,β-unsaturated aldehydes to the corresponding acids have been explored as mentioned in this paper, and the best approach uses sodium chlorite and gives the desired transformation.
Journal ArticleDOI
New methods for the oxidation of aldehydes to carboxylic acids and esters
Journal ArticleDOI
Direct conversion of activated alcohols to azides using diphenyl phosphorazidate. A practical alternative to mitsunobu conditions
TL;DR: In this article, 14 alcohols were converted to their corresponding azides with inversion of configuration using diphenyl phosphorazidate and DBU, and the resulting azides were converted into azides.