Dietary betaine prevents obesity through gut microbiota-drived microRNA-378a family.
Jingjing Du,Peiwen Zhang,Jiang Luo,Linyuan Shen,Shunhua Zhang,Hao Gu,Jin He,Linghui Wang,Xue Zhao,Mailing Gan,Liu Yang,Lili Niu,Ye Zhao,Qianzi Tang,Guoqing Tang,Dongmei Jiang,Yanzhi Jiang,Mingzhou Li,Anan Jiang,Long Jin,Jideng Ma,Surong Shuai,Lin Bai,Jinyong Wang,Bo Zeng,De Wu,Xuewei Li,Li Zhu +27 more
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In this paper, the authors show that Betaine can improve obesity and associated MS via the gut microbiota-derived miR-378a/YY1 regulatory axis, and reveal a novel mechanism by which gut microbiota improve host health.Abstract:
Betaine is a natural compound present in commonly consumed foods and may have a potential role in the regulation of glucose and lipids metabolism However, the underlying molecular mechanism of its action remains largely unknown Here, we show that supplementation with betaine contributes to improved high-fat diet (HFD)-induced gut microbiota dysbiosis and increases anti-obesity strains such as Akkermansia muciniphila, Lactobacillus, and Bifidobacterium In mice lacking gut microbiota, the functional role of betaine in preventing HFD-induced obesity, metabolic syndrome, and inactivation of brown adipose tissues are significantly reduced Akkermansia muciniphila is an important regulator of betaine in improving microbiome ecology and increasing strains that produce short-chain fatty acids (SCFAs) Increasing two main members of SCFAs including acetate and butyrate can significantly regulate the levels of DNA methylation at host miR-378a promoter, thus preventing the development of obesity and glucose intolerance However, these beneficial effects are partially abolished by Yin yang (YY1), a common target gene of the miR-378a family Taken together, our findings demonstrate that betaine can improve obesity and associated MS via the gut microbiota-derived miR-378a/YY1 regulatory axis, and reveal a novel mechanism by which gut microbiota improve host healthread more
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Desulfovibrio vulgaris, a potent acetic acid-producing bacterium, attenuates nonalcoholic fatty liver disease in mice
Ying Hong,Lili Sheng,Jing Zhong,Xin Tao,Weize Zhu,Junli Ma,Juan Yan,Aihua Zhao,Xiaojiao Zheng,Gaosong Wu,Bingbing Li,Bangxing Han,Kan Ding,Ningning Zheng,Wei Jia,Wei Jia,Houkai Li +16 more
TL;DR: In this article, the authors investigated the anti-NAFLD effect of Astragalus polysaccharides (APS) extracted from Astragsalus mongholicus Bunge in high-fat diet (HFD)-fed mice and found that SCFAs, predominantly acetic acid, were elevated in APS-supplemented mice and ex vivo experiment.
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Gut Microbiota Metabolites in Major Depressive Disorder—Deep Insights into Their Pathophysiological Role and Potential Translational Applications
Miguel A Ortega,Miguel Angel Alvarez-Mon,C. García-Montero,Oscar Fraile-Martínez,Luis G. Guijarro,Guillermo Lahera,Jorge Monserrat,Paula Valls,Fernando Mora,Roberto Rodriguez-Jimenez,Javier Quintero,Melchor Alvarez-Mon +11 more
TL;DR: The main microbial metabolites (short-chain fatty acids -SCFAs-, bile acids, amino acids, tryptophan -trp- derivatives, and more), their signaling pathways and functions will be summarized to explain part of MDD pathophysiology.
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Diet-gut microbiota-epigenetics in metabolic diseases: From mechanisms to therapeutics.
TL;DR: In this article , a review aimed to elaborate on the interactions among diet, gut microbiota, and epigenetics to uncover the mechanisms and therapeutics of metabolic diseases, including obesity, dyslipidemia, type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD).
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Rhodomyrtus tomentosa (Ait.) Hassk fruit phenolic-rich extract mitigates intestinal barrier dysfunction and inflammation in mice.
TL;DR: In this article , the mitigative effect of Rhodomyrtus tomentosa (Ait.) Hassk fruit extract rich in phenolic compounds (RTE) on high fat diet (HFD)-induced intestinal barrier dysfunction of mice and the underlying mechanism were explored.
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Recent findings in Akkermansia muciniphila-regulated metabolism and its role in intestinal diseases.
TL;DR: A. muciniphila is a promising probiotic which could be a microbial target for the treatment of multiple intestinal diseases such as irritable bowel syndrome, inflammatory bowel diseases, and intestinal tumors as mentioned in this paper .
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Obesity as a medical problem
TL;DR: The global epidemic of obesity results from a combination of genetic susceptibility, increased availability of high-energy foods and decreased requirement for physical activity in modern society, and should be regarded as an epidemic that threatens global well being.
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TL;DR: Data is reviewed supporting the diverse functional roles carried out by a major class of bacterial metabolites, the short-chain fatty acids (SCFAs), which affect various physiological processes and may contribute to health and disease.
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Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
Eugenia E. Calle,Rudolf Kaaks +1 more
TL;DR: Gaining a better understanding of the relationship between obesity and cancer can provide new insight into mechanisms of cancer pathogenesis.
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