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Journal ArticleDOI

Dietary bioactive compounds and their health implications.

Rui Hai Liu1
01 Jun 2013-Journal of Food Science (John Wiley & Sons, Ltd)-Vol. 78
TL;DR: Consumers should obtain nutrients and bioactive compounds from a wide variety of whole foods for optimal nutrition and health well-being, not from expensive dietary supplements.
Abstract: There is strong scientific evidence suggesting that regular consumption of fruits and vegetables is negatively associated with risk of developing chronic diseases The 2010 Dietary Guidelines for Americans recommend at least 9 servings of fruits and vegetables a day based on a 2000 kcal diet However, the average person in the United States consumes 36 servings of fruits and vegetables per day In order to achieve the goal of at least 9 servings, we should continue educating Americans about the health benefits of fruits and vegetables and recommend consumers to eat a wide variety of fruits and vegetables The key is to increase the amount up to 9 to 13 servings of fruits and vegetables a day in all forms Fresh, cooked, and processed fruits and vegetables including frozen and canned, 100% fruit juices, 100% vegetable juices, and dried fruits are all considered as servings of fruits and vegetables A wide variety of fruits and vegetables provide a range of nutrients and different bioactive compounds including phytochemicals (phenolics, flavonoids, and carotenoids), vitamins (vitamin C, folate, and provitamin A), minerals (potassium, calcium, and magnesium), and fibers More and more evidence suggests that the health benefits of fruits and vegetables are attributed to the additive and synergistic interactions of the phytochemicals present in whole foods by targeting multiple signal transduction pathways Therefore, consumers should obtain nutrients and bioactive compounds from a wide variety of whole foods for optimal nutrition and health well-being, not from expensive dietary supplements
Citations
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Book ChapterDOI
01 Jan 2010

5,842 citations

Journal ArticleDOI
TL;DR: The food changes performed in subjects from the same populations resulted in remarkable reciprocal changes in mucosal biomarkers of cancer risk and in aspects of the microbiota and metabolome known to affect cancer risk, best illustrated by increased saccharolytic fermentation and butyrogenesis and suppressed secondary bile acid synthesis in the African Americans.
Abstract: Rates of colon cancer are much higher in African Americans (65:100,000) than in rural South Africans (<5:100,000). The higher rates are associated with higher animal protein and fat, and lower fibre consumption, higher colonic secondary bile acids, lower colonic short-chain fatty acid quantities and higher mucosal proliferative biomarkers of cancer risk in otherwise healthy middle-aged volunteers. Here we investigate further the role of fat and fibre in this association. We performed 2-week food exchanges in subjects from the same populations, where African Americans were fed a high-fibre, low-fat African-style diet and rural Africans a high-fat, low-fibre western-style diet, under close supervision. In comparison with their usual diets, the food changes resulted in remarkable reciprocal changes in mucosal biomarkers of cancer risk and in aspects of the microbiota and metabolome known to affect cancer risk, best illustrated by increased saccharolytic fermentation and butyrogenesis, and suppressed secondary bile acid synthesis in the African Americans.

724 citations

Journal ArticleDOI
TL;DR: In this paper, the composition and nutritional value of different lettuce types were summarized, which can help growers and consumers choose lettuce types with higher nutritional benefits, such as fiber, iron, folate, and vitamin C.

303 citations

Journal ArticleDOI
TL;DR: Evidence suggests that F&V have the strongest effects in relation to prevention of CVDs, noting a nonlinear threshold effect of 800 g per day (i.e., about 5 servings a day).
Abstract: Fruit and vegetables (FV the 2015–2020 U.S. Dietary Guidelines for Americans recommend that F&V constitute one-half of the plate at eac...

252 citations


Cites background from "Dietary bioactive compounds and the..."

  • ...Upward of 5000 dietary bioactive compounds have been identified to date (Gonzalez-Gallego, V. GarciaMediavilla, S. Sanchez-Campos, and Tunon 2010; Liu 2013; Casas, Estruch, and Sacanella 2018), many of which now have a substantial body of evidence supporting their benefits on human health....

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References
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Journal ArticleDOI
TL;DR: New insights into inflammation in atherosclerosis not only increase the understanding of this disease, but also have practical clinical applications in risk stratification and targeting of therapy for this scourge of growing worldwide importance.
Abstract: Atherosclerosis, formerly considered a bland lipid storage disease, actually involves an ongoing inflammatory response. Recent advances in basic science have established a fundamental role for inflammation in mediating all stages of this disease from initiation through progression and, ultimately, the thrombotic complications of atherosclerosis. These new findings provide important links between risk factors and the mechanisms of atherogenesis. Clinical studies have shown that this emerging biology of inflammation in atherosclerosis applies directly to human patients. Elevation in markers of inflammation predicts outcomes of patients with acute coronary syndromes, independently of myocardial damage. In addition, low-grade chronic inflammation, as indicated by levels of the inflammatory marker C-reactive protein, prospectively defines risk of atherosclerotic complications, thus adding to prognostic information provided by traditional risk factors. Moreover, certain treatments that reduce coronary risk also limit inflammation. In the case of lipid lowering with statins, this anti-inflammatory effect does not appear to correlate with reduction in low-density lipoprotein levels. These new insights into inflammation in atherosclerosis not only increase our understanding of this disease, but also have practical clinical applications in risk stratification and targeting of therapy for this scourge of growing worldwide importance.

7,116 citations

Book ChapterDOI
01 Jan 2010

5,842 citations

Journal ArticleDOI
TL;DR: Flavonoids in regularly consumed foods may reduce the risk of death from coronary heart disease in elderly men and showed an inverse relation with incidence of myocardial infarction.

4,440 citations

Book
01 Jan 1981
TL;DR: Evidence that the various common types of cancer are largely avoidable diseases is reviewed, and it is suggested that, apart from cancer of the respiratory tract, the types of cancers that are currently common are not peculiarly modern diseases and are likely to depend chiefly on some long-established factor.
Abstract: My lecture spanned not only the hour allocated for it in the morning, but also the first half of the round table that afternoon, where it acted as an introduction to the round table discussion that followed. The break between the two sessions was determined only by administrative and not by scientific matters, and so in this published account, the two may be read as a unit.

4,211 citations


"Dietary bioactive compounds and the..." refers background in this paper

  • ...It has been estimated that over 30% of all cancer deaths in the United States are due to dietary choices (Doll and Peto 1981; Willett 1995). Increasing antioxidant defenses through intake of dietary phytochemicals in fruits and vegetables may reduce or delay the oxidation of DNA and affect cellular signal transduction pathways controlling cell proliferation and apoptosis (Liu 2004). The evidence supporting a high intake of fruits and vegetables to prevent cancer is reviewed below. Epidemiological studies have consistently shown that regular consumption of fruits and vegetables can reduce cancer risk. Block and others (1992) reviewed about 200 epidemiological studies that examined the relationship between consumption of fruits and vegetables and cancer of the lung, colon, breast, cervix, esophagus, oral cavity, stomach, bladder, pancreas, and ovary, and concluded that the consumption of fruits and vegetables was related to a reduced risk of cancer incidence. High consumption of fruits particularly had significant protection against cancer of the esophagus, oral cavity, and larynx. The risk of cancer was 2-fold higher in persons with a low intake of fruits and vegetables than in those with a high intake. In a meta-analyses conducted by Steinmetz and Potter (1996), 12 out of 20 prospective cohort studies showed that consumption of fruits and vegetables was statistically negatively associated with reduced risk of cancer. Voorrips and others (2000) reported that consumption of fruits and vegetables was associated with reduced risk of colon cancer in women. In the Nurses’ Health Study, consumption of fruits was inversely related to polyp formation (Michels and others 2006). Women who consumed 5 or more servings of fruit per day had a reduced risk of developing colorectal adenomas when compared to those who ate 1 or fewer servings (odds ratios = 0.6; 95% CI = 0.44 to 0.81). The risk reduction for vegetable consumption was not significant (odds ratios = 0.82, 95% CI = 0.65 to 1.05). Cohen and others (2000) reported that vegetable intake was inversely associated with reduced risk of prostate cancer....

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  • ...It has been estimated that over 30% of all cancer deaths in the United States are due to dietary choices (Doll and Peto 1981; Willett 1995). Increasing antioxidant defenses through intake of dietary phytochemicals in fruits and vegetables may reduce or delay the oxidation of DNA and affect cellular signal transduction pathways controlling cell proliferation and apoptosis (Liu 2004). The evidence supporting a high intake of fruits and vegetables to prevent cancer is reviewed below. Epidemiological studies have consistently shown that regular consumption of fruits and vegetables can reduce cancer risk. Block and others (1992) reviewed about 200 epidemiological studies that examined the relationship between consumption of fruits and vegetables and cancer of the lung, colon, breast, cervix, esophagus, oral cavity, stomach, bladder, pancreas, and ovary, and concluded that the consumption of fruits and vegetables was related to a reduced risk of cancer incidence. High consumption of fruits particularly had significant protection against cancer of the esophagus, oral cavity, and larynx. The risk of cancer was 2-fold higher in persons with a low intake of fruits and vegetables than in those with a high intake. In a meta-analyses conducted by Steinmetz and Potter (1996), 12 out of 20 prospective cohort studies showed that consumption of fruits and vegetables was statistically negatively associated with reduced risk of cancer. Voorrips and others (2000) reported that consumption of fruits and vegetables was associated with reduced risk of colon cancer in women....

    [...]

  • ...It is estimated that more than 30% of all cancer deaths in the United States could be avoided through appropriate life style changes and dietary modification (Doll and Peto 1981; Willet 1995, 2002)....

    [...]

  • ...Dietary phytochemicals in the prevention of cancer It has been estimated that over 30% of all cancer deaths in the United States are due to dietary choices (Doll and Peto 1981; Willett 1995)....

    [...]

  • ...It has been estimated that over 30% of all cancer deaths in the United States are due to dietary choices (Doll and Peto 1981; Willett 1995). Increasing antioxidant defenses through intake of dietary phytochemicals in fruits and vegetables may reduce or delay the oxidation of DNA and affect cellular signal transduction pathways controlling cell proliferation and apoptosis (Liu 2004). The evidence supporting a high intake of fruits and vegetables to prevent cancer is reviewed below. Epidemiological studies have consistently shown that regular consumption of fruits and vegetables can reduce cancer risk. Block and others (1992) reviewed about 200 epidemiological studies that examined the relationship between consumption of fruits and vegetables and cancer of the lung, colon, breast, cervix, esophagus, oral cavity, stomach, bladder, pancreas, and ovary, and concluded that the consumption of fruits and vegetables was related to a reduced risk of cancer incidence. High consumption of fruits particularly had significant protection against cancer of the esophagus, oral cavity, and larynx. The risk of cancer was 2-fold higher in persons with a low intake of fruits and vegetables than in those with a high intake. In a meta-analyses conducted by Steinmetz and Potter (1996), 12 out of 20 prospective cohort studies showed that consumption of fruits and vegetables was statistically negatively associated with reduced risk of cancer....

    [...]

Journal ArticleDOI
TL;DR: Dietary supplementation with n-3 PUFA led to a clinically important and statistically significant benefit and vitamin E had no benefit and its effects on fatal cardiovascular events require further exploration.

3,727 citations