Dietary fructose in nonalcoholic fatty liver disease
Miriam B. Vos,Joel E. Lavine +1 more
Reads0
Chats0
TLDR
Sufficient evidence exists to support clinical recommendations that fructose intake be limited through decreasing foods and drinks high in added (fructose‐containing) sugars.About:
This article is published in Hepatology.The article was published on 2013-06-01 and is currently open access. It has received 270 citations till now. The article focuses on the topics: Nonalcoholic fatty liver disease & High-fructose corn syrup.read more
Citations
More filters
Journal ArticleDOI
Treatment of NAFLD with diet, physical activity and exercise
TL;DR: Clinical evidence strongly supports the role of lifestyle modification as a primary therapy for the management of NAFLD and NASH and should be accompanied by the implementation of strategies to avoid relapse and weight regain.
Journal ArticleDOI
Hepatic inflammation and fibrosis: Functional links and key pathways
Ekihiro Seki,Robert F. Schwabe +1 more
TL;DR: Mechanisms that link inflammation with the development of liver fibrosis are reviewed, focusing on the role of inflammatory mediators in hepatic stellate cell (HSC) activation and HSC survival during fibrogenesis and fibrosis regression.
Journal ArticleDOI
Fructose and sugar: A major mediator of non-alcoholic fatty liver disease
Thomas Jensen,Manal F. Abdelmalek,Shelby Sullivan,Kristen J. Nadeau,Melanie Green,Carlos Roncal,Takahiko Nakagawa,Masanari Kuwabara,Yuka Sato,Duk Hee Kang,Dean R. Tolan,Laura G. Sánchez-Lozada,Hugo R. Rosen,Miguel A. Lanaspa,Anna Mae Diehl,Richard J. Johnson +15 more
TL;DR: Small, more definitive trials are suggested to determine if lowering sugar/HFCS intake, and/or blocking uric acid generation, may help reduce NAFLD and its downstream complications of cirrhosis and chronic liver disease.
Journal ArticleDOI
From NAFLD to NASH to cirrhosis—new insights into disease mechanisms
TL;DR: This Review focuses on recently uncovered aspects of the genetic, biochemical, immunological and molecular events that are responsible for the development and progression of this highly prevalent and potentially serious disease.
Journal ArticleDOI
Liver Cancer: Connections with Obesity, Fatty Liver, and Cirrhosis.
TL;DR: Current evidence linking obesity, NAFLD and liver cancer is summarized, its clinical impact is discussed, and the main mechanisms underlying this complex relationship are described.
References
More filters
Journal ArticleDOI
Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity
Jeffrey D. Browning,Lidia S. Szczepaniak,Robert L. Dobbins,Pamela Nuremberg,Jay D. Horton,Jonathan Cohen,Scott M. Grundy,Helen H. Hobbs +7 more
TL;DR: The prevalence of hepatic steatosis was greater in men than women among whites, but not in blacks or Hispanics, and significant ethnic and sex differences in the prevalence may have a profound impact on susceptibility to Steatosis‐related liver disease.
Journal ArticleDOI
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease.
Kerry L. Donnelly,Coleman Smith,Sarah Jane Schwarzenberg,Jose Jessurun,Mark D. Boldt,Elizabeth J. Parks +5 more
TL;DR: In this article, the authors quantified the biological sources of hepatic and plasma lipoprotein TAG in NAFLD patients, using stable isotopes for four days to label and track serum nonesterified fatty acids (NEFAs), dietary fatty acids, and those derived from the de novo lipogenesis (DNL) pathway, present in liver tissue and lipid TAG.
Journal ArticleDOI
The Natural History of Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study
Leon A. Adams,James F. Lymp,Jenny St. Sauver,Schuyler O. Sanderson,Keith D. Lindor,Ariel E. Feldstein,Paul Angulo +6 more
TL;DR: Mortality among community-diagnosed NAFLD patients is higher than the general population and is associated with older age, impaired fasting glucose, and cirrhosis, although the absolute risk is low.
Journal ArticleDOI
Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
Giulio Marchesini,Elisabetta Bugianesi,Gabriele Forlani,Fernanda Cerrelli,Marco Lenzi,R. Manini,S. Natale,Ester Vanni,Nicola Villanova,Nazario Melchionda,Mario Rizzetto +10 more
TL;DR: The presence of multiple metabolic disorders is associated with a potentially progressive, severe liver disease and the increasing prevalence of obesity, coupled with diabetes, dyslipidemia, hypertension, and ultimately the metabolic syndrome puts a very large population at risk of forthcoming liver failure in the next decades.
Journal ArticleDOI
Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease
TL;DR: Growing evidence suggests that nonalcoholic fatty liver disease is associated with an increased risk of cardiovascular disease beyond that conferred by established risk factors.
Related Papers (5)
Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans
Kimber L. Stanhope,Jean-Marc Schwarz,Jean-Marc Schwarz,Nancy L. Keim,Steven C. Griffen,Andrew A. Bremer,James L. Graham,Bonnie Hatcher,Chad L. Cox,Artem Dyachenko,Wei Zhang,John P. McGahan,Anthony Seibert,Ronald M. Krauss,Sally Chiu,Ernst J. Schaefer,Masumi Ai,Seiko Otokozawa,Katsuyuki Nakajima,Katsuyuki Nakajima,Takamitsu Nakano,Carine Beysen,Marc K. Hellerstein,Lars Berglund,Peter J. Havel +24 more