Differential Behaviors of Atrial Versus Ventricular Fibroblasts A Potential Role for Platelet-Derived Growth Factor in Atrial-Ventricular Remodeling Differences
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...Isolated cardiac fibroblasts have also been shown to have chamber-specific differences with respect to morphology and proliferative responses to stimulation with growth factors.(17) Sheets and strands of fibroblasts are arranged in a 3D network that surrounds myocytes and other cell types....
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...In the heart, atrial and ventricular fibroblasts have different cell densities in intact tissue.(17) Isolated cardiac fibroblasts have also been shown to have chamber-specific differences with respect to morphology and proliferative responses to stimulation with growth factors....
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...However, in a different study, proliferation rates were found to be increased in atrial and ventricular fibroblasts isolated from a canine tachypacing model of congestive heart failure.(17) The same study also showed an increase of platelet-derived growth factor levels in response to tachypacing in fibroblasts isolated from atria but not ventricles....
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...Atria are generally more vulnerable to fibrosis than ventricles (47, 85, 150), which may be due to an enhanced response to multiple growth factors in atrial compared with ventricular CF (17)....
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