Differential regulation of the rainbow trout ( Oncorhynchus mykiss ) MT-A gene by nuclear factor interleukin-6 and activator protein-1
Citations
19 citations
Cites background from "Differential regulation of the rain..."
...The distal region of the rainbow 319 trout mta promoter possess both activator protein 1 (AP1) and a nuclear factor interleukin-6 320 (NF-IL6) elements that have been shown to play a direct role in mta induction in response to 321 paraquat, an herbicide that induces ROS (Kling et al., 2013)....
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...Some pharmaceuticals and personal care products 316 have been shown to affect reactive oxygen species(ROS) production in rainbow trout gonad 317 cell line (RTG-2) (Fernandez et al., 2013) and PAHs are known to induce free radical 318 production (e.g. Wells and Winn 1996; Zhu et al., 2014)....
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...Effects of human 402 pharmaceuticals on cytotoxicity, EROD activity and ROS production in fish hepatocytes....
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...In addition, FIGCS treated with 322 H2O2, that produces ROS, show an increase in mta and b gene expression, as well as other 323 antioxidant genes (Chung et al., 2005)....
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...The antioxidant gene expression is attenuated by the 324 14 zinc chelator N,N,N’,N’-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN), suggesting that the 325 response to ROS in FIGCS is in part mediated by an increase in intracellular zinc 326 concentrations (Chung et al., 2005)....
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14 citations
Cites background from "Differential regulation of the rain..."
...MT promoter activity is regulated by six zinc-finger metalresponsive transcription factor (MTF-1) and a nuclear factor I (NF-I) protein [2]....
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13 citations
Cites background from "Differential regulation of the rain..."
...er region is played by the six zinc-finger-metal-responsive transcription factor (MTF-1) and short cis-acting DNA metal response elements (MREs) as transcriptional activators and a nuclear factor I (NF-I) protein as a downregulator of MT expression [11]....
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12 citations
11 citations
References
127 citations
"Differential regulation of the rain..." refers background in this paper
...However, it has been indicated that ARE driven gene expression can occur in the absence of oxidative stress through the transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf-2) [26]....
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109 citations
"Differential regulation of the rain..." refers background in this paper
...The composite transcription factor AP1 was first identified as a factor mediating optimal basal level expression of the human MT2A (hMT2A) enhancer region [15-17]....
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99 citations
"Differential regulation of the rain..." refers background in this paper
...The role of metallothionein (MT) as a free radical scavenger has been well documented in vitro [3], in cell lines [4], and at the organism level [5,6]....
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96 citations
"Differential regulation of the rain..." refers background in this paper
...suggested that antioxidants such as ascorbate, αtocopherol and β-carotene are inhibitory to differentiation [40]....
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85 citations
"Differential regulation of the rain..." refers background in this paper
...The composite transcription factor AP1 was first identified as a factor mediating optimal basal level expression of the human MT2A (hMT2A) enhancer region [15-17]....
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