Differential regulation of the rainbow trout ( Oncorhynchus mykiss ) MT-A gene by nuclear factor interleukin-6 and activator protein-1
Citations
19 citations
Cites background from "Differential regulation of the rain..."
...The distal region of the rainbow 319 trout mta promoter possess both activator protein 1 (AP1) and a nuclear factor interleukin-6 320 (NF-IL6) elements that have been shown to play a direct role in mta induction in response to 321 paraquat, an herbicide that induces ROS (Kling et al., 2013)....
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...Some pharmaceuticals and personal care products 316 have been shown to affect reactive oxygen species(ROS) production in rainbow trout gonad 317 cell line (RTG-2) (Fernandez et al., 2013) and PAHs are known to induce free radical 318 production (e.g. Wells and Winn 1996; Zhu et al., 2014)....
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...Effects of human 402 pharmaceuticals on cytotoxicity, EROD activity and ROS production in fish hepatocytes....
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...In addition, FIGCS treated with 322 H2O2, that produces ROS, show an increase in mta and b gene expression, as well as other 323 antioxidant genes (Chung et al., 2005)....
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...The antioxidant gene expression is attenuated by the 324 14 zinc chelator N,N,N’,N’-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN), suggesting that the 325 response to ROS in FIGCS is in part mediated by an increase in intracellular zinc 326 concentrations (Chung et al., 2005)....
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14 citations
Cites background from "Differential regulation of the rain..."
...MT promoter activity is regulated by six zinc-finger metalresponsive transcription factor (MTF-1) and a nuclear factor I (NF-I) protein [2]....
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13 citations
Cites background from "Differential regulation of the rain..."
...er region is played by the six zinc-finger-metal-responsive transcription factor (MTF-1) and short cis-acting DNA metal response elements (MREs) as transcriptional activators and a nuclear factor I (NF-I) protein as a downregulator of MT expression [11]....
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12 citations
11 citations
References
30 citations
"Differential regulation of the rain..." refers background in this paper
...Furthermore, it has been shown in a recent study on cod that there is a close correlation between the hepatic levels of ROS and MT [33]....
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...Furthermore, in an open sea study on cod, a strong correlation was observed between hepatic MT levels and the total ROS scavenging capacity of the liver [33]....
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30 citations
"Differential regulation of the rain..." refers background in this paper
...Furthermore, growth hormone (GH) was found to induce the expression of rtMT-A) [48]....
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29 citations
"Differential regulation of the rain..." refers background in this paper
...IL6 and CXCL8 are two of the first inflammatory mediators expressed and contain cis-acting sites for both AP1 and NF-IL6, which indicate their crucial role in acute phase responses [44,45]....
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27 citations
"Differential regulation of the rain..." refers background in this paper
...Sequencing of several teleost MT enhancer regions have revealed the presence of distally located nuclear factor interleukin 6 (NF-IL6) and AP1 elements, inferring that these elements are involved in a conserved function [7,11-13]....
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23 citations
"Differential regulation of the rain..." refers background in this paper
...Kanekiyo and colleagues [46] demonstrated that MT gene activation by zinc regulates macrophage colony stimulating factor (M-CSF), which in turn recruit and stimulate cytokine production by monocytes....
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