Journal ArticleDOI
Dihydrotestosterone, androstenedione, testosterone: Comparative effectiveness in masculinizing and defeminizing reproductive systems in male and female rats
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It was concluded that D, A, and T all possess androgenic properties but that these steroids are differentially effective in different response systems.About:
This article is published in Hormones and Behavior.The article was published on 1970-11-01. It has received 120 citations till now. The article focuses on the topics: Testosterone propionate & Androstenedione.read more
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Book ChapterDOI
The formation of estrogens by central neuroendocrine tissues
Frederick Naftolin,Kenneth J. Ryan,Davies Ij,V V Reddy,F Flores,Z. Petro,Kuhn M,Robert J. White,Yoshiro Takaoka,L.R. Wolin +9 more
TL;DR: Much of what I will discuss here today relates to brain differentiation in rodents, which was the interest of two outstanding British scientists, Geoffrey Harris and Peter MacDonald.
Journal ArticleDOI
Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?
TL;DR: Animal models that mimic fetal androgen excess may provide unique insight into the origins of the PCOS syndrome, and the prenatally androgenized female rhesus monkey shows particular relevance to PCOS.
Journal ArticleDOI
Differentiation of coital behavior in mammals: A comparative analysis
TL;DR: Testicular androgen may cause behavioral defeminization only in those species in which expression of feminine sexual behavior normally depends on the neural action of progesterone, acting synergistically with estradiol; new data support this claim in the ferret.
Journal ArticleDOI
Copulation in Castrated Male Rats following Combined Treatment with Estradiol and Dihydrotestosterone
TL;DR: Castrated male rats injected daily with 2 micrograms of estradiol benzoate (EB) combined with 200 microgramS of dihydrotestosterone propionate (DHTP) displayed masculine mating behavior which was indistinguishable from that of other castrates treated with 200 milligrams of testosterone propionates.
Book ChapterDOI
On the genesis of sexual differentiation of the general nervous system: morphogenetic consequences of steroidal exposure and possible role of alpha-fetoprotein.
TL;DR: This chapter focuses on cellular aspects in the ontogeny of sexual differentiation of the rodent central nervous system (CNS), although the nature or expression of these cellular responses of developing nervous tissue to the gonadal hormones is not peculiar to sexual differentiation.
References
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Journal ArticleDOI
The conversion of testosterone to 5-alpha-androstan-17-beta-ol-3-one by rat prostate in vivo and in vitro.
TL;DR: It has been shown that in the presence of a NADPH2-generating system prostatic nuclei convert testosterone to dihydrotestosterone, whereas prostatic cytoplasm reduces dihydotestosterone to androstandiol.
Journal ArticleDOI
The Upjohn Lecture of the Endocrine Society Sex Hormones, Brain Development and Brain Function12
Journal ArticleDOI
The intranuclear binding of testosterone and 5-alpha-androstan-17-beta-ol-3-one by rat prostate.
TL;DR: It was shown that dihydrotestosterone was bound to an acidic nuclear protein and was stable to freezing for as long as 8 days, stable to short term incubation at 20° but not at 37°, and partially stable to repeated gel filtration on Sephadex.