Dimercaptosuccinic Acid (DMSA), A Non-Toxic, Water-Soluble Treatment For Heavy Metal Toxicity
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6 citations
Cites background from "Dimercaptosuccinic Acid (DMSA), A N..."
...New chelating agents: Succimer 2,3- dimercaptosuccinic acid (succimer, DMSA) has been used since 1950 as an antidote to lead poisoning in Russia, Japan and China (93)....
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...New chelating agents: Succimer 2,3dimercaptosuccinic acid (succimer, DMSA) has been used since 1950 as an antidote to lead poisoning in Russia, Japan and China (93)....
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5 citations
Cites background from "Dimercaptosuccinic Acid (DMSA), A N..."
...Although not conventionally used, DMSA is a well-known molecule, considered non-toxicand orally administrated as a chelating agent to remove heavy metals from an organism representing its biocompatibility (M. P. Garcia et al. 2005; Miller 1998)....
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3 citations
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Cites background from "Dimercaptosuccinic Acid (DMSA), A N..."
...O acúmulo de metais pesados no organismo humano representa um risco significativo para a saúde, levando a uma grande variedade de patologias, como a anemia, o câncer, a insuficiência renal crônica, a hipertensão, a gota, a infertilidade masculina, a gengivite, entre outros (Miller, 1998)....
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...Estes metais são amplamente encontrados em nosso ambiente e os seres humanos são expostos a tais metais a partir de inúmeras fontes, incluindo o ar, a água, o solo e os alimentos (Miller, 1998)....
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2 citations
References
309 citations
"Dimercaptosuccinic Acid (DMSA), A N..." refers background in this paper
...DMSA has been shown in recent studies to be a safe and effective chelator of lead, reducing blood levels significantly.(1,34,35) At a dose of 10 mg/kg for five days in adult males, DMSA lowered blood lead levels 35....
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...DMSA was subsequently studied for twenty years in the People’s Republic of China, Japan, and Russia before scientists in Europe and the United States “discovered” the substance and its potential usefulness in the mid-1970s.(1) DMSA is a dithiol (containing two sulfhydryl, or S-H, groups) and an analogue of dimercaprol (BAL, British Anti-Lewisite), a lipid-soluble compound also used for metal chelation (see Figure 1)....
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196 citations
"Dimercaptosuccinic Acid (DMSA), A N..." refers background in this paper
...Methyl mercury also easily crosses the blood-brain barrier and the placenta.(7) Inorganic and methyl mercury have a high affinity for sulfhydryls, reacting intracellularly with the sulfhydryl group on glutathione and cysteine, and histidine residues in proteins, and allowing transport out of the cell....
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...After lead is absorbed in the human body, it reacts with thiol (sulfhydryl) groups on peptides and proteins, inhibiting enzymes involved in heme synthesis and interfering with normal neurotransmitter functions.(7) This natural reaction with thiols is also the body’s method of eliminating lead, especially from the liver....
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