Dimercaptosuccinic Acid (DMSA), A Non-Toxic, Water-Soluble Treatment For Heavy Metal Toxicity
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Cites background from "Dimercaptosuccinic Acid (DMSA), A N..."
...The drug is 95 % plasma protein bound, most likely by virtue of binding on one of its sulfhydryl groups to a cysteine residue on albumin, leaving the other –SH available to chelate metals [39]....
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Cites background from "Dimercaptosuccinic Acid (DMSA), A N..."
...They found highly elevated pretreatment Hg levels in urine, which they reduced therapeutically with a succimer (DMSA) treatment regimen (Forman et al., 2000; Miller, 1998)....
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287 citations
References
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"Dimercaptosuccinic Acid (DMSA), A N..." refers background or methods in this paper
...DMSA has also been used effectively in arsenic and cadmium poisoning.(2,3,52)...
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...DMSA’s water solubility and oral dosing create a distinct advantage over BAL, which has a small therapeutic index and must be administered in an oil solution via painful, deep intramuscular injection.(2) DMSA, on the other hand, has a large therapeutic window and is the least toxic of the dithiol compounds....
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