Journal ArticleDOI
Diminished effect of maternal age on implantation after preimplantation genetic diagnosis with array comparative genomic hybridization.
Gary Harton,Santiago Munné,Mark Surrey,Jamie Grifo,Brian Kaplan,David H. McCulloh,Darren K. Griffin,Dagan Wells +7 more
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TLDR
Selective transfer of euploid embryos showed that implantation and pregnancy rates were not significantly different between reproductively younger and older patients up to age 42 years, suggesting that the dramatic decline in IVF treatment success rates with female age is primarily caused by aneuploidy.About:
This article is published in Fertility and Sterility.The article was published on 2013-12-01. It has received 263 citations till now. The article focuses on the topics: Pregnancy rate & Preimplantation genetic diagnosis.read more
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Journal ArticleDOI
Preimplantation genetic testing for aneuploidy versus morphology as selection criteria for single frozen-thawed embryo transfer in good-prognosis patients: a multicenter randomized clinical trial.
Santiago Munné,Brian Kaplan,John L. Frattarelli,Tim Child,Gary S. Nakhuda,F. Nicholas Shamma,Kaylen M. Silverberg,Tasha Kalista,Alan H. Handyside,Mandy G. Katz-Jaffe,Dagan Wells,Tony Gordon,Sharyn Stock-Myer,S.P. Willman,Brian D Acacio,Stuart Lavery,Anna Carby,Robert Boostanfar,Robert Forman,Mark Sedler,Anthea Jackson,Keith Jordan,William B. Schoolcraft,S. McReynolds,Vicki L. Schnell,Randall A. Loy,Samuel J. Chantilis,Lowell Ku,John L. Frattarelli,Arlene J. Morales,H. Randall Craig,Mark Perloe,Craig A. Witz,Wei-Hua Wang,J. Wilcox,J.M. Norian,Stephanie Marshall Thompson,Serena Chen,John Garrisi,Renee Walmsley,Robert J. Mendola,Samuel Pang,Denny Sakkas,Kristin L. Rooney,Rita Sneeringer,M.J. Glassner,Leeanda Wilton,Mirjana Martic,Peter Coleman,Stephanie Shepley,Ginny Mounce,Tracey Griffiths,Ronald F. Feinberg,Keith L. Blauer,Brett Reggio,Rachel Rhinehart,William F. Ziegler,Hina Ahmed,Scott Kratka,Evan M. Rosenbluth,K. Ivani,Angela C. Thyer,T. Minter,Charles M. Miller,Mathias Gysler,Pauline Saunders,Robert F. Casper,Deirdre A. Conway,Mark R. Hughes,Michael Large,Joshua Blazek,Elpida Fragouli,Samer Alfarawati +72 more
TL;DR: There was a significant increase in OPR per embryo transfer with the use of PGT-A in the subgroup of women aged 35-40 years who had two or more embryos that could be biopsied, but this was not significant when analyzed by ITT.
Journal ArticleDOI
In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study
Carmen Rubio,José Bellver,Lorena Rodrigo,Gema Castillón,A. Guillen,C. Vidal,Juan Giles,Marcos Ferrando,Sergio Cabanillas,José Remohí,Antonio Pellicer,Carlos Simón +11 more
TL;DR: Preimplantation genetic diagnosis for aneuploidy screening is superior compared with controls not only in clinical outcome at the first ET but also in dramatically decreasing miscarriage rates and shortening the time to pregnancy.
Journal ArticleDOI
Altered Levels of Mitochondrial DNA Are Associated with Female Age, Aneuploidy, and Provide an Independent Measure of Embryonic Implantation Potential
Elpida Fragouli,Katharina Spath,Samer Alfarawati,Fiona Kaper,Andrew Craig,Claude-Edouard Michel,Felix Kokocinski,Jacques Cohen,Santiago Munné,Dagan Wells +9 more
TL;DR: It is proposed that mtDNA content represents a novel biomarker with potential value for in vitro fertilisation (IVF) treatment, revealing chromosomally normal blastocysts incapable of producing a viable pregnancy.
Journal ArticleDOI
Correlation between aneuploidy, standard morphology evaluation and morphokinetic development in 1730 biopsied blastocysts: a consecutive case series study
Maria Giulia Minasi,Alessandro Colasante,Teresa Riccio,Alessandra Ruberti,Valentina Casciani,Filomena Scarselli,Francesca Spinella,Francesco Fiorentino,Maria Teresa Varricchio,Ermanno Greco +9 more
TL;DR: Correlations were observed, in that euploid human blastocysts showed a higher percentage with top quality inner cell mass (ICM) and trophectoderm (TE), higher expansion grades and shorter time to start of blastulation, expansion and hatching, compared to aneuploid ones.
Journal ArticleDOI
Altered Levels of Mitochondrial DNA Are Associated with Female Age, Aneuploidy, and Provide an Independent Measure of Embryonic Implantation Potential
Elpida Fragouli,Katharina Spath,Samer Alfarawati,Fiona Kaper,Andrew Craig,Claude-Edouard Michel,Felix Kokocinski,Jacques Cohen,Santiago Munné,Dagan Wells +9 more
TL;DR: In this article, the authors investigated the extent of variation in mitochondrial DNA (mtDNA) between individual human embryos prior to implantation and suggested that increased mtDNA may be related to elevated metabolism and are associated with reduced viability, a possibility consistent with the ‘quiet embryo' hypothesis.
References
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Journal ArticleDOI
Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte
TL;DR: Intracytoplasmic sperm injection is used to treat couples with infertility because of severely impaired sperm characteristics, and in whom IVF and SUZI had failed.
Journal ArticleDOI
Ice-free cryopreservation of mouse embryos at -196 degrees C by vitrification.
TL;DR: In this article, the authors used mouse embryos to examine the feasibility of obtaining high survival following vitrification of both the intra and extracellular solutions and report that in properly controlled conditions embryos seem to survive in high proportions after cryopreservation in the absence of ice.
Journal ArticleDOI
Embryo morphology, developmental rates, and maternal age are correlated with chromosome abnormalities*
TL;DR: It is demonstrated that, in morphologically and developmentally normal human embryos, cleavage-stage aneuploidy significantly increases with maternal age, and the results suggest that implantation failure in older women largely could be due to aneuPLoidy.
Journal ArticleDOI
Embryo morphology, developmental rates, and maternal age are correlated with chromosome abnormalities**Presented at the 50th Annual Meeting of The American Fertility Society, San Antonio, Texas, November 4 to 9, 1994, where it was awarded the prize paper of the Society for Assisted Reproductive Technology.
TL;DR: It is demonstrated that, in morphologically and developmentally normal human embryos, cleavage-stage aneuploidy significantly increases with maternal age, and the results suggest that implantation failure in older women largely could be due to aneuPLoidy.
Journal ArticleDOI
In vitro fertilization with preimplantation genetic screening.
Sebastiaan Mastenbroek,M. Twisk,Jannie van Echten-Arends,Birgit Sikkema-Raddatz,Johanna C. Korevaar,Harold R. Verhoeve,Niels E. A. Vogel,Eus G. J. M. Arts,Jan W.A de Vries,Patrick M.M. Bossuyt,Charles H.C.M. Buys,Maas Jan Heineman,Sjoerd Repping,Fulco van der Veen +13 more
TL;DR: Preimplantation genetic screening did not increase but instead significantly reduced the rates of ongoing pregnancies and live births after IVF in women of advanced maternal age.