Journal ArticleDOI
Direct C4-Acetoxylation of Tryptophan and Tryptophan-Containing Peptides via Palladium(II)-Catalyzed C-H Activation.
Qiyu Zhang,Xiong Xie,Jingjing Peng,Feiyang Chen,Feiyang Chen,Jinyu Ma,Chunpu Li,Hong Liu,Dechuan Wang,Jiang Wang +9 more
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TLDR
In this article, an efficient regioselective palladium(II)-catalyzed C(sp2)-H 4-acetoxylation of tryptophan and peptides is described.About:
This article is published in Organic Letters.The article was published on 2021-06-01. It has received 6 citations till now. The article focuses on the topics: Tryptophan.read more
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Synthesis of Indole-Fused Six-, Seven-, or Eight-Membered N,O-Heterocycles via Rhodium-Catalyzed NH-Indole-Directed C-H Acetoxylation/Hydrolysis/Annulation.
TL;DR: In this paper, the authors present a facile synthesis of indole-fused six-, seven-, or eight-membered N,O-heterocycles through rhodium-catalyzed C-H acetoxylation/hydrolysis/annulation.
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Pd‐Catalyzed Site‐Selective C(sp2)–H Acetoxylation of Tyrosine‐Containing Peptides
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Synthesis of maleimide-braced peptide macrocycles and their potential anti-SARS-CoV-2 mechanisms.
Jian Lin,Jin-Hyun Sun,Xianglei Zhang,Ruxue Zhang,Qian Wang,Lin Wang,Lei Zhang,Xiong Xie,Chunpu Li,Yun Zhou,Jiang-Hong Wang,Gengfu Xiao,Fang Bai,Hong Lei Liu +13 more
TL;DR: In this paper , the functionalization and macrocyclization of Trp and Trp-containing peptides via Pd(II)-catalyzed C-H alkenylation at the Trp C4 position was reported.
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Palladium(II)-Catalyzed C(sp2)–H Functionalization of Tryptophan and Tryptophan-Containing Peptides
Journal ArticleDOI
Exploring Chemical Modifications of Aromatic Amino Acid Residues in Peptides
TL;DR: In this paper , a review of the strategies for side chain functionalization of four aromatic amino acids in peptides is presented, with a focus on elucidating the underlying mechanisms.
References
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Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions
TL;DR: This is the first comprehensive review encompassing the large body of work in this field over the past 5 years, and will focus specifically on ligand-directed C–H functionalization reactions catalyzed by palladium.
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Aryl-aryl bond formation by transition-metal-catalyzed direct arylation.
TL;DR: A number of improvements have developed the former process into an industrially very useful and attractive method for the construction of aryl -aryl bonds, but the need still exists for more efficient routes whereby the same outcome is accomplished, but with reduced waste and in fewer steps.
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Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents.
TL;DR: The 3,3'-pyrrolidinyl-spirooxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid natural products with strong bioactivity profiles and interesting structural properties.
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C-H bond activation enables the rapid construction and late-stage diversification of functional molecules
TL;DR: This Perspective highlights the potential of metal-catalysed C-H bond activation reactions, which now extend beyond the field of traditional synthetic organic chemistry, and are more atom- and step-economical than previous methods.
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