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Journal ArticleDOI

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

Christopher J L Murray1, Theo Vos2, Rafael Lozano1, Mohsen Naghavi1  +366 moreInstitutions (141)
15 Dec 2012-The Lancet (Elsevier)-Vol. 380, Iss: 9859, pp 2197-2223
TL;DR: The results for 1990 and 2010 supersede all previously published Global Burden of Disease results and highlight the importance of understanding local burden of disease and setting goals and targets for the post-2015 agenda taking such patterns into account.
About: This article is published in The Lancet.The article was published on 2012-12-15. It has received 6861 citations till now. The article focuses on the topics: Disease burden & Disability-adjusted life year.
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TL;DR: The philosophical and methodological aspects of the DALY calculation have been described (and debated) in great detail, but the steps preceding the actual calculation, however, remain less well documented.
Abstract: disability weight ð1Þ YLL 1⁄4 Number of deaths life expectancy at the age of death ð2Þ DALY 1⁄4 YLD þ YLL ð3Þ The philosophical and methodological aspects of the DALY calculation have been described (and debated) in great detail (Murray 1994; Murray and Acharya 1997; for critiques, see, amongst others, Anand and Hanson 1997), and are summarized in the accompanying Hints and Kinks paper (Devleesschauwer et al. 2014). The steps preceding the actual calculation, however, remain less well documented. This Hints and Kinks paper tries to address this gap by presenting a stepwise approach towards a DALY calculation.

104 citations


Cites methods from "Disability-adjusted life years (DAL..."

  • ...The disability-adjusted life year (DALY) is an increasingly used population health metric (Murray et al. 2013; Devleesschauwer et al. 2014)....

    [...]

Journal ArticleDOI
TL;DR: The mental health burden due to depression and anxiety disorders in youth is substantial in LMICs, with high needs but inadequate services, and youth specific services for early detection and cost-effective interventions are needed.

104 citations

Journal ArticleDOI
TL;DR: Extended cost-effectiveness analysis is used to assess the health gains and financial risk protection afforded by a bundle of nine interventions that the Government of Ethiopia aims to make universally available.

103 citations

Journal ArticleDOI
TL;DR: Malaria, leishmaniasis, lymphatic filariasis, and dengue are prime candidates for combined vector control and information on co-endemicity with an assessment of the overlap of vector control methods effective against these diseases allows us to highlight opportunities for such integration.
Abstract: Vector-borne diseases cause a significant proportion of the overall burden of disease across the globe, accounting for over 10 % of the burden of infectious diseases. Despite the availability of effective interventions for many of these diseases, a lack of resources prevents their effective control. Many existing vector control interventions are known to be effective against multiple diseases, so combining vector control programmes to simultaneously tackle several diseases could offer more cost-effective and therefore sustainable disease reductions. The highly successful cross-disease integration of vaccine and mass drug administration programmes in low-resource settings acts a precedent for cross-disease vector control. Whilst deliberate implementation of vector control programmes across multiple diseases has yet to be trialled on a large scale, a number of examples of ‘accidental’ cross-disease vector control suggest the potential of such an approach. Combining contemporary high-resolution global maps of the major vector-borne pathogens enables us to quantify overlap in their distributions and to estimate the populations jointly at risk of multiple diseases. Such an analysis shows that over 80 % of the global population live in regions of the world at risk from one vector-borne disease, and more than half the world’s population live in areas where at least two different vector-borne diseases pose a threat to health. Combining information on co-endemicity with an assessment of the overlap of vector control methods effective against these diseases allows us to highlight opportunities for such integration. Malaria, leishmaniasis, lymphatic filariasis, and dengue are prime candidates for combined vector control. All four of these diseases overlap considerably in their distributions and there is a growing body of evidence for the effectiveness of insecticide-treated nets, screens, and curtains for controlling all of their vectors. The real-world effectiveness of cross-disease vector control programmes can only be evaluated by large-scale trials, but there is clear evidence of the potential of such an approach to enable greater overall health benefit using the limited funds available.

103 citations

Journal ArticleDOI
TL;DR: In this paper, a search was completed for English language studies that longitudinally modeled depressive symptom trajectories in nonclinical populations with a baseline age of <19 years, and twenty studies published between 2002 and 2015 were included.
Abstract: Background With depression predicted to contribute to an increased disease burden in coming decades, prevention efforts have become increasingly important. In order to prevent depression it is valuable to identify and classify longitudinal patterns of depressive symptoms across development, ideally beginning early in childhood. To achieve this, longitudinal studies are increasingly using person‐centered data‐analytic methods to model subgroups with similar developmental patterns (trajectories) of depressive symptoms. Method A search was completed for English language studies that longitudinally modeled depressive symptom trajectories in nonclinical populations with a baseline age of <19 years. Study characteristics were extracted, prevalence rates and risk factors were summarized, a random‐effect meta‐analysis was undertaken, and risk of bias analysis completed. Results Twenty studies published between 2002 and 2015 were included. Participants were recruited at ages 4 through 17 (average age 12.34) and followed longitudinally for an average of 7.45 years. Between 3 and 11 trajectory subgroups were identified. A random pooled effect estimate identified 56% [95% Confidence Interval (CI) 46–65%] of the sampled study populations (N = 41,236) on ‘No or low’ depressive symptom trajectories and 26% (CI 14–40%) on a ‘Moderate’ trajectory. ‘High’, ‘Increasing’, and ‘Decreasing’ depressive symptom subgroups were evident for 12% (CI 8–17%). Moderate symptoms were associated with poorer adjustment and outcomes relative to low symptom groups. ‘High’ or ‘Increasing’ trajectories were predominantly predicted by: female gender, low socioeconomic status, higher stress reactivity; conduct issues; substance misuse, and problems in peer and parental relationships. Conclusions The review highlighted consistent evidence of subgroups of children and adolescents who differ in their depressive symptom development over time. The findings suggest preventative interventions should evaluate the longer term benefits of increasing membership in low and moderate trajectories, while also targeting reductions in high‐risk subgroups. Considerable between‐study method and measurement variation indicate the need for future trajectory studies to use standardized methods.

103 citations


Cites background from "Disability-adjusted life years (DAL..."

  • ...Depression is predicted to become one of the highest contributors to the global burden of disease in coming decades (e.g., Murray et al., 2012)....

    [...]

References
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Journal ArticleDOI
Rafael Lozano1, Mohsen Naghavi1, Kyle J Foreman2, Stephen S Lim1  +192 moreInstitutions (95)
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2010 aimed to estimate annual deaths for the world and 21 regions between 1980 and 2010 for 235 causes, with uncertainty intervals (UIs), separately by age and sex, using the Cause of Death Ensemble model.

11,809 citations

Book
01 Jan 1996
TL;DR: This is the first in a planned series of 10 volumes that will attempt to "summarize epidemiological knowledge about all major conditions and most risk factors" and use historical trends in main determinants to project mortality and disease burden forward to 2020.
Abstract: This is the first in a planned series of 10 volumes that will attempt to "summarize epidemiological knowledge about all major conditions and most risk factors;...generate assessments of numbers of deaths by cause that are consistent with the total numbers of deaths by age sex and region provided by demographers;...provide methodologies for and assessments of aggregate disease burden that combine--into the Disability-Adjusted Life Year or DALY measure--burden from premature mortality with that from living with disability; and...use historical trends in main determinants to project mortality and disease burden forward to 2020." This first volume includes chapters summarizing results from the project as a whole. (EXCERPT)

7,154 citations

Journal ArticleDOI
Theo Vos, Abraham D. Flaxman1, Mohsen Naghavi1, Rafael Lozano1  +360 moreInstitutions (143)
TL;DR: Prevalence and severity of health loss were weakly correlated and age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010, but population growth and ageing have increased YLD numbers and crude rates over the past two decades.

7,021 citations

Journal ArticleDOI
TL;DR: The three leading contributors to the burden of disease are communicable and perinatal disorders affecting children, and the substantial burdens of neuropsychiatric disorders and injuries are under-recognised.

4,425 citations