Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
TL;DR: The results for 1990 and 2010 supersede all previously published Global Burden of Disease results and highlight the importance of understanding local burden of disease and setting goals and targets for the post-2015 agenda taking such patterns into account.
About: This article is published in The Lancet.The article was published on 2012-12-15. It has received 6861 citations till now. The article focuses on the topics: Disease burden & Disability-adjusted life year.
Citations
More filters
TL;DR: Lymphatic filariasis and other neglected tropical diseases, notably Buruli Ulcer, cutaneous leishmaniasis, leprosy, yaws, onchocerciasis and trachoma cause significant co morbidity associated with mental illness in patients, which will contribute a significant burden of co-morbidity attributable to mental illness.
Abstract: Neglected Tropical Diseases (NTDs) afflict around one billion individuals in the poorest parts of the world with many more at risk Lymphatic filariasis is one of the most prevalent of the infections and causes significant morbidity in those who suffer the clinical conditions, particularly lymphedema and hydrocele Depressive illness has been recognised as a prevalent disability in those with the disease because of the stigmatising nature of the condition No estimates of the burden of depressive illness of any neglected tropical disease have been undertaken to date despite the recognition that such diseases have major consequences for mental health not only for patients but also their caregivers We developed a mathematical model to calculate the burden of Disability- Adjusted Life Years (DALY) attributable to depressive illness in lymphatic filariasis and that of their caregivers using standard methods for calculating DALYs Estimates of numbers with clinical disease was based on published estimates in 2012 and the numbers with depressive illness from the available literature We calculated that the burden of depressive illness in filariasis patients was 509 million disability-adjusted life years (DALYs) and 229,537 DALYs attributable to their caregivers These figures are around twice that of 278 million DALYs attributed to filariasis by the Global Burden of Disease study of 2010 Lymphatic filariasis and other neglected tropical diseases, notably Buruli Ulcer, cutaneous leishmaniasis, leprosy, yaws, onchocerciasis and trachoma cause significant co morbidity associated with mental illness in patients Studies to assess the prevalence of the burden of this co-morbidity should be incorporated into any future assessment of the Global Burden of neglected tropical diseases The prevalence of depressive illness in caregivers who support those who suffer from these conditions is required Such assessments are critical for neglected tropical diseases which have such a huge global prevalence and thus will contribute a significant burden of co-morbidity attributable to mental illness
102 citations
TL;DR: Interactions between species, particularly where one is likely to be a pathogen of the other, as well as the geographical distribution of species, have been systematically extracted from various web-based, free-access sources, and assembled with the accompanying evidence into a single database.
Abstract: Interactions between species, particularly where one is likely to be a pathogen of the other, as well as the geographical distribution of species, have been systematically extracted from various web-based, free-access sources, and assembled with the accompanying evidence into a single database. The database attempts to answer questions such as what are all the pathogens of a host, and what are all the hosts of a pathogen, what are all the countries where a pathogen was found, and what are all the pathogens found in a country. Two datasets were extracted from the database, focussing on species interactions and species distribution, based on evidence published between 1950–2012. The quality of their evidence was checked and verified against well-known, alternative, datasets of pathogens infecting humans, domestic animals and wild mammals. The presented datasets provide a valuable resource for researchers of infectious diseases of humans and animals, including zoonoses.
102 citations
TL;DR: The results revealed that the MDD and BD patients were more similar than different in GMV and RSFC, which indicates that investigating the frontal-limbic system could be useful for understanding the underlying mechanisms of these two disorders.
102 citations
Cites background from "Disability-adjusted life years (DAL..."
...Introduction Major depressive disorder (MDD) and bipolar disorder (BD) are common, severe affective diseases that affect people throughout the world (Gonda et al., 2012; Murray et al., 2013)....
[...]
...Major depressive disorder (MDD) and bipolar disorder (BD) are common, severe affective diseases that affect people throughout the world (Gonda et al., 2012; Murray et al., 2013)....
[...]
TL;DR: The prevention of dementia and the development of long-term care policies and plans for people with dementia in LA, which take into account regional differences and similarities, should be urgent priorities.
Abstract: Population aging is among the most important global transformations. Today, 12% of the world population is age 60 and over and by the middle of this century this segment will represent 21.5%. The increase in the population aged 80 an over, also referred to as the “oldest old” or the “very elderly”, will be even more pronounced, going from 1.7% of the population to 4.5% within the same period. Compared to European and North American countries, Latin America is experiencing this unprecedented demographic change at a significantly faster rate. Due to demographic and health transitions, the number of people with dementia will rise form 7.8 million in 2013 to over 27 million by 2050. Nowadays, the global prevalence of dementia in Latin America has reached 7.1%, with Alzheimer's disease being the most frequent type. This level is similar to those found in developed countries; however, the dementia rate is twice as high as that of the 65 - 69 years age group in developed countries. In addition, the prevalence and incidence of dementia is higher among illiterate people. Mortality rates due to dementia have risen considerably, while survival rates have decreased. The burden and costs of the disease are high and must be covered by patients' families. The prevention of dementia and the development of long-term care policies and plans for people with dementia should be urgent priorities in Latin America, considering the similarities and differences within the Region.
102 citations
Cites background from "Disability-adjusted life years (DAL..."
...In Central America, they occupy the 50th spot, the 62nd in Andean LA and the 26th in South America (Murray et al., 2012)....
[...]
...In Chile, they are the fastest-growing diseases in terms of DALY causation: 200% between 1990 and 2010 (Murray et al., 2012)....
[...]
...In the Andean part of LA, they are the 68th cause and the 53th in South America, with major intra-regional disparities (Lozano et al., 2012; Prince et al., 2016)....
[...]
TL;DR: Birth in an urban environment is associated with an increased risk for mental illness in general and for a broad range of specific psychiatric disorders, and further work is needed to identify the underlying aetiopathogenic mechanisms.
Abstract: Background People born in densely populated areas have a higher risk of developing schizophrenia, bipolar disorder and autism. Aims The purpose of this study was to investigate whether urban–rural differences in place of birth influence a broad range of mental disorders. Method Population-based cohort study of everyone born in Denmark between 1955 and 2006 ( n = 2 894 640). Main outcome measures were incidence rate ratios for five levels of urbanisation and summary estimates contrasting birth in the capital with birth in rural areas. Results For all psychiatric disorders, except intellectual disability (ICD-10 ‘mental retardation’) and behavioural and emotional disorders with onset in childhood, people born in the capital had a higher incidence than people born in rural areas. Conclusions Birth in an urban environment is associated with an increased risk for mental illness in general and for a broad range of specific psychiatric disorders. Given this new evidence that urban–rural differences in incidence are not confined to the well-studied psychotic disorders, further work is needed to identify the underlying aetiopathogenic mechanisms.
102 citations
References
More filters
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2010 aimed to estimate annual deaths for the world and 21 regions between 1980 and 2010 for 235 causes, with uncertainty intervals (UIs), separately by age and sex, using the Cause of Death Ensemble model.
11,809 citations
Book•
01 Jan 1996
TL;DR: This is the first in a planned series of 10 volumes that will attempt to "summarize epidemiological knowledge about all major conditions and most risk factors" and use historical trends in main determinants to project mortality and disease burden forward to 2020.
Abstract: This is the first in a planned series of 10 volumes that will attempt to "summarize epidemiological knowledge about all major conditions and most risk factors;...generate assessments of numbers of deaths by cause that are consistent with the total numbers of deaths by age sex and region provided by demographers;...provide methodologies for and assessments of aggregate disease burden that combine--into the Disability-Adjusted Life Year or DALY measure--burden from premature mortality with that from living with disability; and...use historical trends in main determinants to project mortality and disease burden forward to 2020." This first volume includes chapters summarizing results from the project as a whole. (EXCERPT)
7,154 citations
TL;DR: Prevalence and severity of health loss were weakly correlated and age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010, but population growth and ageing have increased YLD numbers and crude rates over the past two decades.
7,021 citations
TL;DR: The three leading contributors to the burden of disease are communicable and perinatal disorders affecting children, and the substantial burdens of neuropsychiatric disorders and injuries are under-recognised.
4,425 citations