Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
TL;DR: The results for 1990 and 2010 supersede all previously published Global Burden of Disease results and highlight the importance of understanding local burden of disease and setting goals and targets for the post-2015 agenda taking such patterns into account.
About: This article is published in The Lancet.The article was published on 2012-12-15. It has received 6861 citations till now. The article focuses on the topics: Disease burden & Disability-adjusted life year.
Citations
More filters
••
TL;DR: Findings from cohort studies show that increased nut consumption is associated with a reduced risk of cardiovascular disease and mortality, and their association with decreased mortality suggests a potential in reducing disease burden, including cardiovascular disease, cancer, and cognitive impairments.
79 citations
••
TL;DR: Increased representation of global signal correlation (GSCORR) in DMN regions, as confirmed independently by degree of centrality (DC) and by an independent DMN template is demonstrated for the first time.
79 citations
••
TL;DR: A comprehensive overview about schistosomiasis including recent trends in the number of people treated with praziquantel and the latest developments in diagnosis and control is presented.
Abstract: In the current era of intensified and integrated control against schistosomiasis and other neglected tropical diseases, there is a need to carefully rethink and take into consideration disease-specific issues pertaining to the diagnosis, prevention, control and local elimination. Here, we present a comprehensive overview about schistosomiasis including recent trends in the number of people treated with praziquantel and the latest developments in diagnosis and control. Particular emphasis is placed on children. Identified research needs are offered for consideration; namely, expanding our knowledge about schistosomiasis in preschool-aged children, assessing and quantifying the impact of schistosomiasis on infectious and noncommunicable diseases, developing new antischistosomal drugs and child-friendly formulations, designing and implementing setting-specific control packages and developing highly sensitive, but simple diagnostic tools that are able to detect very light infections in young children and in people living in areas targeted for schistosomiasis elimination.
79 citations
••
Erasmus University Rotterdam1, Dokuz Eylül University2, University of North Carolina at Chapel Hill3, University of Michigan4, Harvard University5, University of Adelaide6, University of Groningen7, Rush University Medical Center8, University of Edinburgh9, VU University Amsterdam10, King's College London11, Lundbeck12, University of Queensland13, Aarhus University14, University of Lausanne15, University of Basel16, Northwestern University17, University of Münster18, Brigham and Women's Hospital19, University of Trento20, Hoffmann-La Roche21, Helsinki University Central Hospital22, Boston Children's Hospital23, National Institutes of Health24, University of Texas Health Science Center at Houston25, QIMR Berghofer Medical Research Institute26, German Center for Neurodegenerative Diseases27, Kaiser Permanente28, Washington University in St. Louis29, University of Greifswald30, Max Planck Society31, Columbia University32, Technische Universität München33, University of Helsinki34, Stanford University35, University College London36, Janssen Pharmaceutica37, University of Exeter38, Boston University39, University of Tartu40, Aarhus University Hospital41, University of Mississippi42, University of Liverpool43, University of Bonn44, Queensland University of Technology45, Cardiff University46, Florida Atlantic University47, University of Iowa48, Icahn School of Medicine at Mount Sinai49, Heidelberg University50, Ludwig Maximilian University of Munich51, University of Göttingen52, Group Health Cooperative53, James Cook University54, University Medical Center Groningen55, Greifswald University Hospital56
TL;DR: The results support a continuum between depressive symptoms and major depressive disorder, and a phenotypically more inclusive approach may help to achieve the large sample sizes needed to detect susceptibility loci for depression.
79 citations
••
TL;DR: Reducing injury mortality in low- and middle-income countries could save over 2 million lives per year and provide significant economic benefit globally.
Abstract: Objectives
Injury is a significant source of morbidity and mortality worldwide, and often disproportionately affects younger, more productive members of society. While many have made the case for improved injury prevention and trauma care, health system development in low- and middle-income countries is often limited by resources. This study aims to determine the economic benefit of improved injury prevention and trauma care in low- and middle-income countries.
Methods
This study uses existing data on injury mortality worldwide from the 2010 Global Burden of Disease Study to estimate the number of lives that could be saved if injury mortality rates in low- and middle-income countries could be reduced to rates in high-income countries. Using economic modeling – through the human capital approach and the value of a statistical life approach – the study then demonstrates the associated economic benefit of these lives saved.
Results
88 percent of injury-related deaths occur in low- and middle-income countries. If injury mortality rates in low- and middle-income countries were reduced to rates in high-income countries, 2,117,500 lives could be saved per year. This would result in between 49 million and 52 million disability adjusted life years averted per year, with discounting and age weighting. Using the human capital approach, the associated economic benefit of reducing mortality rates ranges from $245 to $261 billion with discounting and age weighting. Using the value of a statistical life approach, the benefit is between 758 and 786 billion dollars per year.
Conclusions
Reducing injury mortality in low- and middle-income countries could save over 2 million lives per year and provide significant economic benefit globally. Further investments in trauma care and injury prevention are needed.
79 citations
References
More filters
••
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2010 aimed to estimate annual deaths for the world and 21 regions between 1980 and 2010 for 235 causes, with uncertainty intervals (UIs), separately by age and sex, using the Cause of Death Ensemble model.
11,809 citations
•
01 Jan 1996
TL;DR: This is the first in a planned series of 10 volumes that will attempt to "summarize epidemiological knowledge about all major conditions and most risk factors" and use historical trends in main determinants to project mortality and disease burden forward to 2020.
Abstract: This is the first in a planned series of 10 volumes that will attempt to "summarize epidemiological knowledge about all major conditions and most risk factors;...generate assessments of numbers of deaths by cause that are consistent with the total numbers of deaths by age sex and region provided by demographers;...provide methodologies for and assessments of aggregate disease burden that combine--into the Disability-Adjusted Life Year or DALY measure--burden from premature mortality with that from living with disability; and...use historical trends in main determinants to project mortality and disease burden forward to 2020." This first volume includes chapters summarizing results from the project as a whole. (EXCERPT)
7,154 citations
••
TL;DR: Prevalence and severity of health loss were weakly correlated and age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010, but population growth and ageing have increased YLD numbers and crude rates over the past two decades.
7,021 citations
••
TL;DR: The three leading contributors to the burden of disease are communicable and perinatal disorders affecting children, and the substantial burdens of neuropsychiatric disorders and injuries are under-recognised.
4,425 citations