Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
TL;DR: The results for 1990 and 2010 supersede all previously published Global Burden of Disease results and highlight the importance of understanding local burden of disease and setting goals and targets for the post-2015 agenda taking such patterns into account.
About: This article is published in The Lancet.The article was published on 2012-12-15. It has received 6861 citations till now. The article focuses on the topics: Disease burden & Disability-adjusted life year.
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TL;DR: The newly released version of the Global Burden of Disease (GBD 2010) ranks migraine between the most disabling diseases, the first among neurological ones, with a two-fold increase with respect to the previous GBD 2000 version.
Abstract: The newly released version of the Global Burden of Disease (GBD 2010) ranks migraine between the most disabling diseases, the first among neurological ones, with a two-fold increase with respect to the previous GBD 2000 version. Almost 3 % of worldwide disability attributable to a specific disease, in terms of years lived with a disability, is due to migraine. The public health impact of migraine and headache disorders is thus a consolidated fact; however, further research is needed to provide stronger recognition of and policy actions for headache disorders in general, and in particular with regard to chronic forms of headache.
76 citations
TL;DR: It is shown clearly that there is greater diversity in CYP distribution in Africa than in other continental populations and a need for optimization of drug therapy and drug development there.
76 citations
Cites background from "Disability-adjusted life years (DAL..."
...Based on a study calculating worldwide disease burden for 21 regions, the African continent has 15.5% of the global population but carries approximately 25% of the global disease burden (Murray et al., 2012)....
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TL;DR: In this paper, the focus areas where environmental engineering should assume a more active presence in the global community that seeks to achieve sustainability in developing regions of the world are reviewed. And the 10 environmental engineering Grand Challenges for the developing world covered are: (1) understand the historical perspective of the discipline's connection with public health as the field transitions forward; (2) integ...
Abstract: The environmental engineering discipline has focused much of its historical efforts in developing regions of the world on advancing environmental sustainability through improving provision of water, sanitation, and hygiene (WASH) services. However, the skills and expertise that reside within the discipline of environmental engineering are fundamental to achieve a much broader range of sustainable development goals, including those related to health, climate, water, energy, and food security; economic development; and reduction of social inequalities. Accordingly, this article critically reviews several focus areas where environmental engineering should assume a more active presence in the global community that seeks to achieve sustainability in developing regions of the world. The 10 environmental engineering Grand Challenges for the developing world covered are: (1) understand the historical perspective of the discipline's connection with public health as the field transitions forward; (2) integ...
76 citations
Cites background from "Disability-adjusted life years (DAL..."
..., cancer, cardiovascular diseases, diabetes, endocrine diseases); the opposite is true for higher-income countries (Murray et al., 2012)....
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...By 2010, musculoskeletal disorders, injuries, mental and behavioral disorders, cancer, and cardiovascular diseases comprised a greater percentage of the overall health burden (Murray et al., 2012)....
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...…tuberculosis, respiratory infections, and other communicable diseases cause a greater disease burden in developing regions than noncommunicable diseases (e.g., cancer, cardiovascular diseases, diabetes, endocrine diseases); the opposite is true for higher-income countries (Murray et al., 2012)....
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...This shift was not observed in less developed regions such as South Asia, Oceania, and sub-Saharan Africa, where the majority of the disease burden continues to originate from communicable diseases, neonatal disorders, and nutritional deficiencies (Murray et al., 2012)....
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TL;DR: Impaired functional connectivity between the anterior insula and the inferior parietal lobule of the ECN distinguishes patients with bipolar depression from those with unipolar depression and healthy control subjects, highlighting a pathophysiological mechanism with potential as a therapeutic target and a clinical biomarker for bipolar disorder.
76 citations
TL;DR: The deep brain stimulation of ventral anterior cingulate cortex evokes rapid mood improvements in subgroups of treatment-resistant depressive patients, likely mediated by a functional remodelling of cortico-limbic circuits, and this supports the usefulness of glutamatergic transmission as a new area in antidepressant drug development.
76 citations
References
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TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2010 aimed to estimate annual deaths for the world and 21 regions between 1980 and 2010 for 235 causes, with uncertainty intervals (UIs), separately by age and sex, using the Cause of Death Ensemble model.
11,809 citations
Book•
01 Jan 1996
TL;DR: This is the first in a planned series of 10 volumes that will attempt to "summarize epidemiological knowledge about all major conditions and most risk factors" and use historical trends in main determinants to project mortality and disease burden forward to 2020.
Abstract: This is the first in a planned series of 10 volumes that will attempt to "summarize epidemiological knowledge about all major conditions and most risk factors;...generate assessments of numbers of deaths by cause that are consistent with the total numbers of deaths by age sex and region provided by demographers;...provide methodologies for and assessments of aggregate disease burden that combine--into the Disability-Adjusted Life Year or DALY measure--burden from premature mortality with that from living with disability; and...use historical trends in main determinants to project mortality and disease burden forward to 2020." This first volume includes chapters summarizing results from the project as a whole. (EXCERPT)
7,154 citations
TL;DR: Prevalence and severity of health loss were weakly correlated and age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010, but population growth and ageing have increased YLD numbers and crude rates over the past two decades.
7,021 citations
TL;DR: The three leading contributors to the burden of disease are communicable and perinatal disorders affecting children, and the substantial burdens of neuropsychiatric disorders and injuries are under-recognised.
4,425 citations