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Journal ArticleDOI

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

Christopher J L Murray, +369 more
- 15 Dec 2012 - 
- Vol. 380, Iss: 9859, pp 2197-2223
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TLDR
The results for 1990 and 2010 supersede all previously published Global Burden of Disease results and highlight the importance of understanding local burden of disease and setting goals and targets for the post-2015 agenda taking such patterns into account.
About
This article is published in The Lancet.The article was published on 2012-12-15. It has received 6861 citations till now. The article focuses on the topics: Disease burden & Disability-adjusted life year.

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Stress and Telomere Biology: A Lifespan Perspective

TL;DR: A better understanding of the mechanisms that govern and regulate telomere biology throughout the lifespan may inform the understanding of etiology and the long-term consequences of stress and mental illnesses on aging processes in diverse populations and settings.
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The α-Thalassemias

TL;DR: More than 100 varieties of α-thalassemia have been identified and their geographic distribution and the challenges associated with screening, diagnosis, and management suggest they should have a higher priority on global public health agendas.
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Human health impacts of ecosystem alteration

TL;DR: This work discusses what is known about the human health implications of changes in the structure and function of natural systems and proposes that these changes are affecting human health in a variety of important ways.
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Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory.

TL;DR: A mechanism-based rationale for the use of HA in some disease conditions with special reference to OA is provided, and the MW of HA appears to play a critical role in the formulation of the products used in the treatment of diseases.
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Non-communicable disease syndemics: poverty, depression, and diabetes among low-income populations.

TL;DR: This Series paper examines the application of syndemic theory to comorbidity and multimorbidities in low-income and middle-income countries and illustrates the different syndemics across these countries and the potential benefit of Syndemic care to patients.
References
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Journal ArticleDOI

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

Rafael Lozano, +195 more
- 15 Dec 2012 - 
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2010 aimed to estimate annual deaths for the world and 21 regions between 1980 and 2010 for 235 causes, with uncertainty intervals (UIs), separately by age and sex, using the Cause of Death Ensemble model.
Book

The global burden of disease: a comprehensive assessment of mortality and disability from diseases injuries and risk factors in 1990 and projected to 2020.

TL;DR: This is the first in a planned series of 10 volumes that will attempt to "summarize epidemiological knowledge about all major conditions and most risk factors" and use historical trends in main determinants to project mortality and disease burden forward to 2020.
Journal ArticleDOI

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

Theo Vos, +363 more
- 15 Dec 2012 - 
TL;DR: Prevalence and severity of health loss were weakly correlated and age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010, but population growth and ageing have increased YLD numbers and crude rates over the past two decades.
Journal ArticleDOI

Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study

TL;DR: The three leading contributors to the burden of disease are communicable and perinatal disorders affecting children, and the substantial burdens of neuropsychiatric disorders and injuries are under-recognised.
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Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

Rafael Lozano, +195 more
- 15 Dec 2012 - 

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

Theo Vos, +363 more
- 15 Dec 2012 - 

A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

Stephen S Lim, +210 more
- 15 Dec 2012 -