Journal ArticleDOI
Disappearance rates of endogenous follicle-stimulating hormone in serum following surgical hypophysectomy in man.
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The disappearance rates of endogenous FSH in serum following complete hypophysectomy were determined in 5 patients and the hormone concentrations were measured by specific radioimmunoassays.Abstract:
The disappearance rates of endogenous FSH in serum following complete hypophysectomy were determined in 5 patients. Simultaneous determinations of serum FSH and LH were made in one patient. The hormone concentrations were measured by specific radioimmunoassays. Endogenous FSH disappears from circulation at a much slower rate than endogenous LH (approximately 10-fold). The disappearance rates for FSH, like that of LH, could be resolved into at least 2 exponential components. The initial fast component has a mean t½ of 3.9 hr, which was followed by a second slow component with a mean t½ of 70.4 hr.read more
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Book ChapterDOI
The neuroendocrine control of the menstrual cycle.
TL;DR: The construction of a model of the neuroendocrine control system that governs the 28-day ovarian cycle of the rhesus monkey is discussed, which has three basic components: the arcuate nucleus of the hypothalamus, the gonadotrophs of the pituitary gland, and the ovary.
Journal ArticleDOI
Insulin resistance in nonobese patients with polycystic ovarian disease.
TL;DR: The results indicate that in PCO, a significant degree of insulin resistance exists, which clearly is not related to obesity.
Journal ArticleDOI
Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome.
TL;DR: Data indicate that in these PCO patients the abnormalities of the hypothalamic-pituitary regulation of gonadotropin secretion was not an inherent defect but represented a functional derangement consequent to inappropriate estrogen feedback, which led to a vicious cycle of chronic anovulation and inappropriate gonadotropic secretion.
Journal ArticleDOI
Biologic effects of transdermal estradiol.
Ryszard J. Chetkowski,David R. Meldrum,Kenneth A. Steingold,Denise Randle,John K. H. Lu,Peter Eggena,Jerome M. Hershman,Norma Alkjaersig,Anthony P. Fletcher,Howard L. Judd +9 more
TL;DR: A dose–response study in 23 postmenopausal women to compare the physiologic effects of transdermal estradiol and oral conjugated equine estrogens found both preparations lowered gonadotropin levels, decreased the percentages of vaginal parabasal cells, increased the percentage of superficial cells, and lowered urinary calcium excretion.
Journal ArticleDOI
Hormonal Dynamics at Midcycle: A Reevaluation*
TL;DR: The data provide a relatively precise picture of the hormonal changes preceding the onset of the gonadotropin surge and the temporal relationship between the multiphasic P4 rise and pituitary-ovarian function.
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