Discovery of Human Zinc Deficiency: Its Impact on Human Health and Disease
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Cites background from "Discovery of Human Zinc Deficiency:..."
...Complete recovery occurred after high-dose zinc supplementation [21]....
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"Discovery of Human Zinc Deficiency:..." refers background in this paper
...Additional studies also showed that zinc decreased LPS-, ROS-, or TNF-a-induced NF-kB activation in endothelial cells and cancer cells (46)....
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...In this study, we observed that zinc decreased oxLDL-induced generation of TNF-a, IL-1b, and VCAM-1, oxidative stress markers, and activation of NF-kB and increased A20 and PPAR-2 proteins in humanmonocytic and vascular endothelial cells....
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...Zinc-supplemented subjects showed significant decreases in LPS-induced TNF-a and IL-1b mRNA and TNF-induced NF-kB DNA binding in mononuclear cells (MNCs) compared with the placebo group (55)....
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...Zinc decreased the generation of TNF-a, IL-1b, VCAM-1, and MDA+HAEs in HL-60 and THP-1 and HAECs after incubation with oxidized LDL (oxLDL) for 24 h compared with zinc-deficient cells....
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...In nested case-control and prospective trials, it was shown that IL-1b, IL-6, TNF-a, and CRP were elevated several years before the onset of type 2 diabetes (80,84)....
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"Discovery of Human Zinc Deficiency:..." refers background in this paper
...Zinc deficiency decreases circulating insulin-like growth factor 1 (IGF-1) concentration independent of total energy intake (29)....
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