Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease
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...The Journal of Comparative Neurology | Research in Systems Neuroscience 3881 classical studies documenting the loss of neurons in degenerative diseases, for example correlating the extent of neuron loss with disease severity (Damier et al., 1999; Stark and Pakkenberg, 2004; Kordower et al., 2013)....
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...This is consistent with the pattern of nigrostriatal degeneration that is believed to occur in PD patients, based on evidence from human postmortem studies, functional neuroimaging, genetic causes of the disease, and neurotoxin animal models.(29,30) In agreement with this, LB-induced accumulations of FIGURE 6: a-Synuclein pathology in Lewy bodies (LB)-injected monkeys....
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...Our results indicate that nigral LB extracts derived from PD patients are able to initiate a slowly progressive nigrostriatal neurodegenerative process affecting initially and more extensively dopaminergic axon terminals in the striatum rather than SNpc cell bodies, which is consistent with the pattern of nigrostriatal degeneration occurring in PD patients.(29,30)...
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368 citations
Cites background from "Disease duration and the integrity ..."
...PD is a common neurodegenerative disease, pathologically characterised by the loss of dopaminergic neurons (see Glossary) in the substantia nigra pars compacta (SNc) [3]....
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361 citations
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