Dissolving microneedle patches for dermal vaccination
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TLDR
This review focuses on dissolving microneedles that after penetration into the skin dissolve releasing the encapsulated antigen, and the immunogenicity of antigens formulated in dissolvingmicroneedle are addressed.Abstract:
The dermal route is an attractive route for vaccine delivery due to the easy skin accessibility and a dense network of immune cells in the skin. The development of microneedles is crucial to take advantage of the skin immunization and simultaneously to overcome problems related to vaccination by conventional needles (e.g. pain, needle-stick injuries or needle re-use). This review focuses on dissolving microneedles that after penetration into the skin dissolve releasing the encapsulated antigen. The microneedle patch fabrication techniques and their challenges are discussed as well as the microneedle characterization methods and antigen stability aspects. The immunogenicity of antigens formulated in dissolving microneedles are addressed. Finally, the early clinical development is discussed.read more
Citations
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Advances in transdermal insulin delivery.
TL;DR: Different transdermal insulin delivery techniques and their respective advantages and limitations are focused on, including chemical enhancers-promoted, electrically enhanced, mechanical force-triggered, and microneedle-assisted methods.
Composite Dissolving Microneedles for Coordinated Control of Antigen and Adjuvant Delivery Kinetics in Transcutaneous Vaccination
Peter C. DeMuth,Wilfredo F. Garcia-Beltran,Michelle Lim Ai-Ling,Paula T. Hammond,Darrell J. Irvine +4 more
TL;DR: In comparison to traditional needle‐based vaccination, microneedle delivery gives improved cellular immunity and equivalent generation of serum antibodies, suggesting the potential of this approach for vaccine delivery.
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3D printed microneedles for anticancer therapy of skin tumours.
Jasim Uddin,Nicolaos Scoutaris,Sophia N. Economidou,Clementine Giraud,Babur Z. Chowdhry,Ryan F. Donnelly,Dennis Douroumis +6 more
TL;DR: 3D printed polymeric microneedle arrays fabricated for enhanced cisplatin delivery to A-431 epidermoid skin tumours for cancer treatment demonstrates the potential for in-vivo transdermal delivery of anticancer drugs.
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Microneedles for painless transdermal immunotherapeutic applications
Hamed Amani,Mohammad-Ali Shahbazi,Mohammad-Ali Shahbazi,Carmine D'Amico,Flavia Fontana,Samin Abbaszadeh,Hélder A. Santos +6 more
TL;DR: Microneedles possess many outstanding properties, such as the ability for the painless traverse of the stratum corneum, minimal invasiveness, facile fabrication, excellent biocompatibility, convenient administration, and bypassing first-pass metabolism that allows direct translocation of therapeutics into the systematic circulation.
Implantable Silk Composite Microneedles for Programmable Vaccine Release Kinetics and Enhanced Immunogenicity in Transcutaneous Immunization
TL;DR: Use of this platform to deliver a model whole‐protein vaccine with optimized release kinetics resulted in >10‐fold increases in antigen‐specific T‐cell and humoral immune responses relative to traditional parenteral needle‐based immunization.
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TL;DR: The already significant impact this field has made on the administration of various pharmaceuticals is discussed; limitations of the current technology are explored; methods under exploration for overcoming these limitations and the challenges ahead are discussed.
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TL;DR: Building off a strong technology base and multiple demonstrations of successful drug delivery, microneedles are poised to advance further into clinical practice to enable better pharmaceutical therapies, vaccination and other applications.
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Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery
TL;DR: Results indicate that biodegradable polymer microneedles can be fabricated with an appropriate geometry and sufficient strength to insert into skin, and thereby dramatically increase transdermal transport of molecules.