Distinct Dimer Interaction and Regulation in Nitric-oxide Synthase Types I, II, and III
Koustubh Panda,Robin J. Rosenfeld,Sanjay Ghosh,Abigail L. Meade,Elizabeth D. Getzoff,Dennis J. Stuehr +5 more
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TLDR
The results indicate that the three NOS isozymes, despite their general structural similarity, differ markedly in their strengths, interfaces, and in how l-Arg and H4B influence their formation and stability.About:
This article is published in Journal of Biological Chemistry.The article was published on 2002-08-23 and is currently open access. It has received 127 citations till now. The article focuses on the topics: Dimer.read more
Citations
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Journal ArticleDOI
iNOS-mediated nitric oxide production and its regulation.
TL;DR: The prevention of the overproduction of NO in the living organism through control of regulatory pathways may assist in the treatment of high NO-mediated disorders without changing physiological levels of NO.
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The physiology and pathophysiology of nitric oxide in the brain.
TL;DR: Nitric oxide is a well-known vasorelaxant agent, but it works as a neurotransmitter when produced by neurons and is also involved in defense functions when it is produced by immune and glial cells.
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Vascular Consequences of Endothelial Nitric Oxide Synthase Uncoupling for the Activity and Expression of the Soluble Guanylyl Cyclase and the cGMP-Dependent Protein Kinase
TL;DR: The present review summarizes current concepts concerning eNOS uncoupling and also focuses on the consequences for downstream signaling with respect to activity and expression of the sGC and cGK-I in various diseases.
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Inducible Nitric Oxide Synthase: Regulation, Structure, and Inhibition
TL;DR: A better understanding of iNOS’ complex functions is necessary before specific drug candidates can be identified for classical indications such as sepsis, heart failure, and pain; however, newer promising indications for iN OS inhibition, such as depression, neurodegenerative disorders, and epilepsy, have been discovered.
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eNOS uncoupling and endothelial dysfunction in aged vessels
TL;DR: ENOS uncoupling and increased nitrosylation of eNOS, decreased expressions of GTP cyclohydrolase I and sepiapterin reductase, and subsequent reduced BH4 bioavailability may be important contributors of endothelial dysfunction in aged vessels are suggested.
References
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The CCP4 suite: programs for protein crystallography
TL;DR: The CCP4 (Collaborative Computational Project, number 4) program suite is a collection of programs and associated data and subroutine libraries which can be used for macromolecular structure determination by X-ray crystallography.
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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination
Axel T. Brunger,Axel T. Brunger,Paul D. Adams,G M Clore,W. L. DeLano,Piet Gros,R.W. Grosse-Kunstleve,R.W. Grosse-Kunstleve,Jiansheng Jiang,J. Kuszewski,Michael Nilges,Navraj S. Pannu,Randy J. Read,Luke M. Rice,Thomas Simonson,Gregory L. Warren +15 more
TL;DR: The Crystallography & NMR System (CNS) as mentioned in this paper is a software suite for macromolecular structure determination by X-ray crystallography or solution nuclear magnetic resonance (NMR) spectroscopy.
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Nitric oxide and macrophage function
TL;DR: Although the high-output NO pathway probably evolved to protect the host from infection, suppressive effects on lymphocyte proliferation and damage to other normal host cells confer upon NOS2 the same protective/destructive duality inherent in every other major component of the immune response.
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Solvent-Accessible Surfaces of Proteins and Nucleic Acids
TL;DR: A method is presented for analytically calculating a smooth, three-dimensional contour about a molecule, which has been applied in enzymology, rational drug design, immunology, and understanding DNA base sequence recognition.
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Analytical molecular surface calculation
TL;DR: In this paper, a computer algorithm is presented for calculating the part of the van der Waals surface of a molecule that is accessible to solvent, where the solvent molecule is modeled by a sphere and a sphere is, in effect, rolled over the molecule to generate a smooth outer surface contour.