Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient.
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...Foxl1 in mice marks a population of subepithelial telocytes that are essential for the intestinal stem-cell niche (Shoshkes-Carmel et al., 2018; Kaestner, 2019; McCarthy et al., 2020)....
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...Similar opposing gradients were reported in the microenvironment of the adult mouse gut (McCarthy et al., 2020)....
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"Distinct Mesenchymal Cell Populatio..." refers background in this paper
...Furthermore, mutations that activate Wnt signaling are obligate events in colorectal cancer (CRC) and inactivating SMAD4 and SMAD2 mutations, which override BMP differentiation activity, are also common somatic defects (Fearon and Vogelstein, 1990; Cancer Genome Atlas Network, 2012)....
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