Distinct Sets of Genetic Alterations in Melanoma
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...Arthralgia Grade 2 60 (18) 1 (<1) Grade 3 11 (3) 2 (<1) Rash Grade 2 33 (10) 0 Grade 3 28 (8) 0 Fatigue Grade 2 38 (11) 33 (12) Grade 3 6 (2) 5 (2) Cutaneous squamous-cell carcinoma‡ Grade 3 40 (12) 1 (<1) Keratoacanthoma§ Grade 2 7 (2) 0 Grade 3 20 (6) 0 Nausea Grade 2 25 (7) 32 (11) Grade 3 4 (1) 5 (2) Alopecia Grade 2 26 (8)¶ 0 Pruritus Grade 2 19 (6) 0 Grade 3 5 (1) 0 Hyperkeratosis Grade 2 17 (5) 0 Grade 3 4 (1) 0 Diarrhea Grade 2 16 (5) 4 (1) Grade 3 2 (<1) 1 (<1) Headache Grade 2 15 (4) 5 (2) Grade 3 2 (<1) 0 Vomiting Grade 2 9 (3) 14 (5) Grade 3 4 (1) 3 (1) Neutropenia Grade 2 1 (<1) 4 (1) Grade 3 0 15 (5) Grade 4 1 (<1) 8 (3)...
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...Australia or New Zealand 39 (12) 38 (11)...
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...05), consistent with previous studies (Curtin et al., 2005), as well as MDM2 and TERT (p < 0....
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...We also observed high-level focal CNAs containing the oncogenes CDK4 and CCND1 (p 0.01, FDR 0.05), consistent with previous studies (Curtin et al., 2005), as well as MDM2 and TERT (p 0.05, FDR 0.05) to be significantly enriched in Triple-WTmelanomas (Figures 2B and 2C)....
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