Distinctive nuclear organisation of centromeres and regions involved in pluripotency in human embryonic stem cells
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Cites background from "Distinctive nuclear organisation of..."
...In another system, no significant differences in the extent of centromere clustering were observed between undifferentiated human ES cells and two diploid differentiated cell types, including a lymphoblastoid cell line (FATO LCL) and primary fibroblasts (Wiblin et al., 2005)....
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...However, centromeres in ES cells were mainly found within the nuclear interior, whereas, in differentiated cells, centromeres tend to localize at the nuclear periphery (Wiblin et al., 2005)....
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707 citations
Cites background from "Distinctive nuclear organisation of..."
...For example, comparable distributions of centromeres and of promyelocytic leukaemia (PML) bodies (which are implicated in transcription, apoptosis and cellular stress processes) are found in both human ES cells and differentiated cell...
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References
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"Distinctive nuclear organisation of..." refers background or methods in this paper
...In differentiated cells, gene-rich domains and regions of coordinately regulated gene expression, loop out from CTs (Volpi et al., 2000; Mahy et al., 2002a)....
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...5 (Mahy et al., 2002a)....
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...Gene clusters, and individual chromosomal domains also have distinctive localisations within respect to their CTs (Volpi et al., 2000; Williams et al., 2002; Mahy et al., 2002a)....
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...Analysis of probe position relative to the surface of CTs, and interphase separation (d) were as previously described (Mahy et al., 2002a; Mahy et al., 2002b; Chambeyron and Bickmore, 2004)....
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...We measured the distances between hybridisation signals for BACs for the specific loci, and the visible edge of the hybridisation signal for the corresponding CT (Mahy et al., 2002)....
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229 citations
"Distinctive nuclear organisation of..." refers background in this paper
...Their nuclear distribution has not been extensively studied, but many transcriptionally active genomic regions, including parts of the major histocompatibility complex (MHC) at 6p, are reported to be associated with them (Wang et al., 2004)....
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206 citations
"Distinctive nuclear organisation of..." refers background in this paper
...Gene clusters, and individual chromosomal domains also have distinctive localisations within respect to their CTs (Volpi et al., 2000; Williams et al., 2002; Mahy et al., 2002a)....
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...Within CTs themselves, the position of gene clusters is altered in different differentiated human cell types (Volpi et al., 2000; Williams et al., 2002)....
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190 citations
"Distinctive nuclear organisation of..." refers background in this paper
...Centromeres are also generally found at the nuclear periphery, or around nucleoli (Carvalho et al., 2001; Weierich et al., 2003; Gilchrist et al., 2004), whereas telomeres are mainly found in the nuclear interior (Weierich et al....
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...Centromeres are also generally found at the nuclear periphery, or around nucleoli (Carvalho et al., 2001; Weierich et al., 2003; Gilchrist et al., 2004), whereas telomeres are mainly found in the nuclear interior (Weierich et al., 2003)....
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...Telomeres are dispersed throughout the nucleoplasm of differentiated cells (Weierich et al., 2003)....
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...Human centromeres are localised close to either the nuclear periphery or the nucleolus (Carvalho et al., 2001; Weierich et al., 2003)....
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..., 2004), whereas telomeres are mainly found in the nuclear interior (Weierich et al., 2003)....
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122 citations
"Distinctive nuclear organisation of..." refers background in this paper
...However, to date no significant change in radial position of a human chromosome within the nucleus had been documented during differentiation, although there may be changes in chromosome associations (Kuroda et al., 2004)....
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...changes in chromosome associations (Kuroda et al., 2004)....
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...However, to date no significant change in radial position of a human chromosome within the nucleus has been documented during differentiation, although there may be changes in chromosome associations (Kuroda et al., 2004)....
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