Distinctive patterns of histone H4 acetylation are associated with defined sequence elements within both heterochromatic and euchromatic regions of the human genome
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36 citations
Cites background from "Distinctive patterns of histone H4 ..."
...2 Because HP1α and histone H3 trimethylated at lysine 9 (H3 Me K9) are enriched in constitutive heterochromatin while H3 Me K4 and various forms of N-terminally acetylated H4 (H4 Ac) are depleted in heterochromatic regions (Johnson et al. 1998; Jenuwein and Allis 2001), we analyzed 4q35....
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...Because HP1α and histone H3 trimethylated at lysine 9 (H3 Me K9) are enriched in constitutive heterochromatin while H3 Me K4 and various forms of N-terminally acetylated H4 (H4 Ac) are depleted in heterochromatic regions (Johnson et al. 1998; Jenuwein and Allis 2001), we analyzed 4q35....
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...In the vicinity of long and short D4Z4 arrays, we recently looked for one attribute of constitutive heterochromatin, namely strong hypoacetylation of histone H4 (Johnson et al. 1998) at 4q35....
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34 citations
Cites background from "Distinctive patterns of histone H4 ..."
...1995), and acetylated K8 and K16 is commonly enriched in transcriptionally active and potentially active chromatin (Turner 1993; Roth and Allis 1996; Johnson et al. 1998; Wittschieben et al. 2000)....
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...…to histone deposition on newly synthesized chromatin during S phase in several species (Sobel et al. 1995), and acetylated K8 and K16 is commonly enriched in transcriptionally active and potentially active chromatin (Turner 1993; Roth and Allis 1996; Johnson et al. 1998; Wittschieben et al. 2000)....
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31 citations
Cites background from "Distinctive patterns of histone H4 ..."
...Moreover, it has been noted that the degree of acetylation of K16 increased in the coding regions of DNA in human cells (Johnson et al., 1998)....
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31 citations
Cites background from "Distinctive patterns of histone H4 ..."
...5–9 times less Sat3 immunoprecipitated than for either silent or expressed gene regions in euchromatin [Johnson et al., 1998]....
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...It was reported that immunoprecipitates analyzed by slot-blot hybridization show varying extents of hypoacetylation of heterochromatin relative to either unexpressed or expressed euchromatin [O’Neill and Turner, 1995; Johnson et al., 1998]....
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31 citations
Cites background from "Distinctive patterns of histone H4 ..."
...More than 10 specific modifications of histones are known to date, but it has been found that the acetylation of the lysine at position 8 of histone 4 correlates most strongly with the activation of chromatin on a promoter preceeding the initiation of transcription [15]....
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