Distinctive patterns of histone H4 acetylation are associated with defined sequence elements within both heterochromatic and euchromatic regions of the human genome
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...Repetitive sequences located in constitutive heterochromatin were associated with under-acetylated H4 isoforms, whereas telomeric hexamer repeat sequences showed H4AcK16 levels similar to those in coding regions (37)....
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...Chromatin immunoprecipitation (ChIP) assays with antibodies to acetylated H4, however, did reveal associations of the H4AcK16 isoform with genomic regions or specific genes in human lymphoblasts (37)....
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...A 3- to 5-fold drop in the acetylation of centric heterochromatin occurred on differentiation of both male (not shown) and female cells (Figures 5 and 6), and by day 4 it had reached the low level characteristic of adult cells (O’Neill and Turner, 1995; Johnson et al., 1998)....
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...Levels of H4 acetylation in this region are higher than we have observed previously in genes and chromosome domains from a variety of cell types (O’Neill and Turner, 1995; Johnson et al., 1998)....
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...Chromatin was immunoprecipitated with affinity-purified antibodies to acetylated H4 exactly as described previously (O’Neill and Turner, 1995; Johnson et al., 1998)....
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...Specific DNA sequences were detected by hybridization with 32P-labelled DNA probes and quantified on a PhosphorImager (Molecular Dynamics) as described previously (O’Neill and Turner, 1995; Johnson et al., 1998)....
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75 citations
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Cites background from "Distinctive patterns of histone H4 ..."
...and euchromatic regions and has been linked to gene activation (30, 33, 41)....
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