Distribution and Diffusion of Solutes in Articular Cartilage
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TLDR
The molal distribution coefficients of small uncharged molecules like urea are close to unity, which indicates that all water in cartilage seems to behave as solvent water, and for larger molecules the distribution as well as the diffusion coefficients decrease with increase in molecular weight and are very sensitive to variations in fixed charge density.About:
This article is published in Biophysical Journal.The article was published on 1970-05-01 and is currently open access. It has received 308 citations till now.read more
Citations
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Transport of Molecules in the Tumor Interstitium: A Review
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Diffusion in brain extracellular space.
Eva Syková,Charles Nicholson +1 more
TL;DR: Experimental studies with the real-time iontophoresis method employing the cation tetramethylammonium in normal brain tissue improve the conception of ECS structure and the roles of glia and extracellular matrix in modulating the ECS microenvironment.
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Fluid transport and mechanical properties of articular cartilage: A review
TL;DR: This review is aimed at unifying the understanding of cartilage viscoelastic properties in compression, in particular the role of compression-dependent permeability in controlling interstitial fluid flow and its contribution to the observed vis coelastic effects.
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Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage. I. Chemical composition.
M Venn,A Maroudas +1 more
TL;DR: In post-mortem cartilage water content decreased from a maximum at the surface to a minimum in the deep zones and in the osteoarthrotic specimens water content was greatest in the middle zones, where glycosaminoglycan content was highest.
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Factors involved in the nutrition of the human lumbar intervertebral disc: cellularity and diffusion of glucose in vitro.
TL;DR: Calculated findings and derived values for glucose utilization in disc tissue indicate that nutritional conditions in the intervertebral disc are more critical than, for example, in articular cartilage.
References
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Journal ArticleDOI
A physical interpretation of the phenomenological coefficients of membrane permeability.
O. Kedem,A. Katchalsky +1 more
TL;DR: A "translation" of the phenomenological permeability coefficients into friction and distribution coefficients amenable to physical interpretation is presented and a set of equations and reference curves are presented for the evaluation of ω and σ in the transport of polyvalent ions through charged membranes.
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Physicochemical Properties of Cartilage in the Light of Ion Exchange Theory
TL;DR: The concentration of fixed negatively-charged groups in cartilage was shown to be the most important parameter and fixed charge density was found to increase with distance from the articular surface and this variation was reflected in the other properties.
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The correlation of fixed negative charge with glycosaminoglycan content of human articular cartilage
TL;DR: In the 25–60 age group neither the hexuronic acid nor the total hexosamine contents showed any correlation with the age of the subject, however, there was considerable local variation and variation between individuals.
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The interaction of collagen and acid mucopolysaccharides. A model for connective tissue
TL;DR: A schematic model for the interaction of collagen and chondroitin sulphate-protein macromolecules shows parallel-ordered interaction ofcollagen fibrils withChondroit in sulphate side chains of the chond Detroitin sulphATE-proteinmacromolecule, which appears mainly dependent on electrostatic forces and is increased with increase in chain length of the polysaccharide.
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Triton X-100 scintillant for carbon-14 labelled materials.
TL;DR: Touluene/Triton X-100 liquid scintillant has been found to possess excellent characteristics for the counting of a wide variety of carbon-14 labelled compounds and shows considerable resistance to quenching effects from aqueous samples, particularly aqueously acids.