Distribution and location of genetic effects for dairy traits
John B. Cole,Paul M. VanRaden,Jeffrey R. O'Connell,C.P. Van Tassell,Tad S. Sonstegard,Robert D. Schnabel,Jeremy F. Taylor,G.R. Wiggans +7 more
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TLDR
A high-density scan using 38,416 single nucleotide polymorphism markers for 5,285 bulls confirmed 2 previously known major genes on Bos taurus autosomes (BTA) 6 and 14 but revealed few other large effects as discussed by the authors.About:
This article is published in Journal of Dairy Science.The article was published on 2009-06-01 and is currently open access. It has received 224 citations till now. The article focuses on the topics: Quantitative trait locus & Allele.read more
Citations
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Invited review: reliability of genomic predictions for North American Holstein bulls.
Paul M. VanRaden,C.P. Van Tassell,G.R. Wiggans,Tad S. Sonstegard,Robert D. Schnabel,Jeremy F. Taylor,Flavio S Schenkel +6 more
TL;DR: Genotypes for 38,416 markers and August 2003 genetic evaluations for 3,576 Holstein bulls born before 1999 were used to predict January 2008 daughter deviations and genomic prediction improves reliability by tracing the inheritance of genes even with small effects.
Journal ArticleDOI
Hot topic: a unified approach to utilize phenotypic, full pedigree, and genomic information for genetic evaluation of Holstein final score.
TL;DR: A national single-step genetic evaluation with the pedigree relationship matrix augmented with genomic information provided genomic predictions with accuracy and bias comparable to multiple-step procedures and could account for any population or data structure.
Journal ArticleDOI
Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle
Hans D. Daetwyler,Aurélien Capitan,Hubert Pausch,Paul Stothard,Rianne van Binsbergen,R.F. Brøndum,Xiaoping Liao,Anis Djari,Sabrina Rodriguez,Cécile Grohs,Diane Esquerre,Olivier Bouchez,Marie-Noelle Rossignol,Christophe Klopp,Dominique Rocha,Sébastien Fritz,André Eggen,Phil J. Bowman,David Coote,Amanda J. Chamberlain,Charlotte Anderson,Curt P VanTassell,Ina Hulsegge,Michael E. Goddard,Bernt Guldbrandtsen,M.S. Lund,Roel F. Veerkamp,Didier Boichard,Ruedi Fries,Ben J. Hayes +29 more
TL;DR: The 1000 bull genomes project supports the goal of accelerating the rates of genetic gain in domestic cattle while at the same time considering animal health and welfare by providing the annotated sequence variants and genotypes of key ancestor bulls.
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The QTN Program and the Alleles That Matter for Evolution: All That’s Gold Does Not Glitter
TL;DR: It is argued that neither theory nor data justify a view of readily discoverable large‐effect alleles as the primary molecular substrates for evolution, and that evolution often acts via large numbers of small‐effect polygenes, individually undetectable.
Journal ArticleDOI
Computing procedures for genetic evaluation including phenotypic, full pedigree, and genomic information
TL;DR: The proposed methodology may allow the upgrading of an existing evaluation to incorporate the genomic information when the information attributable to genomics can be expressed as modifications to the numerator relationship matrix.
References
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Complex vertebral malformation in holstein calves.
TL;DR: A recently observed lethal congenital defect of purebred Holstein calves is reported in this paper, characterized by shortening of the cervical and thoracic parts of the vertebral column due to multiple hemivertebrae, fused and misshaped vertebrae and scoliosis.
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Extent of linkage disequilibrium in Holstein cattle in North America.
TL;DR: It is suggested that to capture useful LD, which is required for whole-genome fine mapping and genomic selection, a denser SNP map would be needed.
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Whole genome scan to detect quantitative trait loci for conformation and functional traits in dairy cattle
TL;DR: In this granddaughter design, consisting of 20 Holstein Friesian grandsires and 833 sons, genotypes were determined for 277 microsatellite markers covering the whole genome, and the presence of 61 quantitative trait loci when 27 were expected by chance was suggested.
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OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily.
Neela Patel,Els C. M. Brinkman-Van der Linden,Scott W. Altmann,Kurt Gish,Sriram Balasubramanian,Jackie C. Timans,David O. Peterson,Marcum P. Bell,J. Fernando Bazan,Ajit Varki,Robert A. Kastelein +10 more
TL;DR: The identification of OB-BP1/Siglec-6 as a Siglec family member, coupled with its restricted expression pattern, suggests that it may mediate cell-cell recognition events by interacting with sialylated glycoprotein ligands expressed on specific cell populations.
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Quantitative trait loci mapping of functional traits in the German Holstein cattle population
Ch. Kühn,Jörn Bennewitz,Norbert Reinsch,N. Xu,Hauke Thomsen,C. Looft,Gudrun A. Brockmann,Manfred Schwerin,C. Weimann,Stefan Hiendleder,Georg Erhardt,I. Medjugorac,M. Förster,Bertram Brenig,F. Reinhardt,R. Reents,Ingolf Russ,G. Averdunk,J. Blümel,Ernst Kalm +19 more
TL;DR: The results suggest that loci with influence on udder health may also contribute to genetic variance of longevity.