Journal ArticleDOI
Divergent and stereocontrolled approach to the synthesis of uracil nucleosides branched at the anomeric position
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This article is published in Journal of Organic Chemistry.The article was published on 1995-02-01. It has received 56 citations till now.read more
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Methods and compositions for treating hepatitis C virus
TL;DR: A method and composition for treating a host infected with hepatitis C comprising administering an effective hepatitis C treatment amount of a described 1′, 2′ or 3′-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided in this paper.
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3′-or 2′-hydroxymethyl substituted nucleoside derivatives for treatment of hepatitis virus infections
TL;DR: In this article, a composition for and a method of treating hepatitis B virus (HBV) infection, hepatitis C virus (HCV), hepatitis D virus (HDV), or a proliferative disorder in a patient using an effective amount of a compound selected from the group consisting of formulas (I)-(IV) below and mixtures of two or more thereof, wherein the substituents are as defined herein.
Patent
2-branched nucleosides and flaviviridae mutation
TL;DR: A method for the treatment of Flaviviridae infection that includes the administration of a 2-branched nucleoside, or a pharmaceutically acceptable prodrug and/or salt thereof, to a human in need of therapy in combination or alternation with a drug that directly or indirectly induces a mutation in the viral genome at a location other than a mutation of a nucleotide that results in a change from serine to a different amino acid in the highly conserved consensus sequence, XRXSGXXXT, or is associated with such a mutation as discussed by the authors
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Applications of CeCl3 as an Environmental Friendly Promoter in Organic Chemistry
Patent
1'-substituted carba-nucleoside analogs for antiviral treatment
TL;DR: In this paper, pyrrolo, imidazo, triazolo and triazinyl nucleosides were used for the treatment of hepatitis C infection, where the 1′ position of the nucleoside sugar was substituted.