Divergent Significance of Bone Mineral Density Changes in Aging Depending on Sites and Sex Revealed through Separate Analyses of Bone Mineral Content and Area
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Separate analyses of BMC and area change revealed that the significance of aBMD changes in aging was very divergent among sites and between sexes, suggesting that the authors should be more cautious when interpreting the meaning of a BMD change.Abstract:
Bone mineral density (aBMD) is equivalent to bone mineral content (BMC) divided by area We rechecked the significance of aBMD changes in aging by examining BMC and area separately Subjects were 1167 community-dwelling Japanese men and women, aged 40–79 years ABMDs of femoral neck and lumbar spine were assessed by DXA twice, at 6-year intervals The change rates of BMC and area, as well as aBMD, were calculated and described separately by the age stratum and by sex In the femoral neck region, aBMDs were significantly decreased in all age strata by an increase in area as well as BMC loss in the same pattern in both sexes In the lumbar spine region, aBMDs decreased until the age of 60 in women, caused by the significant BMC decrease accompanying the small area change Very differently in men, aBMDs increased after their 50s due to BMC increase, accompanied by an area increase Separate analyses of BMC and area change revealed that the significance of aBMD changes in aging was very divergent among sites and between sexes This may explain in part the dissociation of aBMD change and bone strength, suggesting that we should be more cautious when interpreting the meaning of aBMD changeread more
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References
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Updated Data on Proximal Femur Bone Mineral Levels of US Adults
Anne C. Looker,Heinz W. Wahner,William L. Dunn,Mona S. Calvo,Tamara Harris,Stephen P. Heyse,C. Conrad Johnston,R. Lindsay +7 more
TL;DR: The updated data on BMD for the total femur ROI of NHW have been selected as the reference database for femur standardization efforts by the International Committee on Standards in Bone Measurements.
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B. Lawrence Riggs,L. Joseph Melton,Richard A. Robb,Jon J. Camp,Elizabeth J. Atkinson,James M. Peterson,Peggy A Rouleau,Cynthia H. McCollough,Mary L. Bouxsein,Sundeep Khosla +9 more
TL;DR: Over life, the cross‐sectional area of the vertebrae and proximal femur increased by ∼15% in both sexes, whereas vBMD at these sites decreased by 39–55% and 34–46%, respectively, with greater decreases in women than in men.
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TL;DR: Bone mineral density (BMD) predicts fracture and can be used in combination with age to estimate absolute risk of fractures in postmenopausal white women as mentioned in this paper, but there are insufficient data to translate BMD results into risk of fracture for men and nonwhite women.
Clinical Use of Bone DensitometryScientific Review
TL;DR: Data from the prospective Study of Osteoporotic Fractures is used to estimate risk of fracture from bone density and age in postmenopausal women and guidelines based on systematic reviews and a cost-effectiveness analysis suggest that it is worthwhile to measure BMD in white women older than 65 years and perhaps to use risk factors to select younger post menopausal women for densitometry.
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