Journal ArticleDOI
Divinorin A, a psychotropic terpenoid, and divinorin B from the hallucinogenic Mexican mint, Salvia divinorum
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This article is published in Journal of Organic Chemistry.The article was published on 1984-11-01. It has received 172 citations till now. The article focuses on the topics: Salvia divinorum.read more
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Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist
Bryan L. Roth,Karen Baner,Richard B. Westkaemper,Daniel J. Siebert,Kenner C. Rice,Seanna Steinberg,Paul Ernsberger,Richard B. Rothman +7 more
TL;DR: Salvinorin A is the first naturally occurring nonnitrogenous opioid-receptor subtype-selective agonist for κ opioid receptors and may represent novel psychotherapeutic compounds for diseases manifested by perceptual distortions (e.g., schizophrenia, dementia, and bipolar disorders).
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Constituents from Salvia species and their biological activities.
TL;DR: This paper aims to provide a history of forensic medicine in China and its applications in the field of regenerative medicine, as well as some examples of how modern forensic medicine has changed over time.
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Salvia divinorum and salvinorin A: new pharmacologic findings
TL;DR: The diterpene salvinorin A from Salvia divinorum (Epling and Jativa-M), in doses of 200-500 micrograms produces effects which are subjectively identical to those experienced when the whole herb is ingested.
Journal ArticleDOI
Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations.
Charles Chavkin,Sumit Sud,Wenzhen Jin,Jeremy Stewart,Jordan K. Zjawiony,Daniel J. Siebert,Beth Ann Toth,Sandra J. Hufeisen,Bryan L. Roth +8 more
TL;DR: Salvinorin A was found to be a full agonist, being significantly more efficacious than (trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl] benzeneacetamide methane-sulfonate hydrate (U69593) and similar in efficacy to dynorphin A (the naturally occurring peptide ligand for κ-opioid receptors).
Journal ArticleDOI
Pattern of use and subjective effects of Salvia divinorum among recreational users.
TL;DR: The observed simultaneous high scores on the LSD and PCAG subscales of the Addiction Research Center Inventory (ARCI) have been previously reported for other kappa-opioid agonists, and support kappa receptor activation as the probable pharmacologic mechanism underlying the modified state of awareness induced by salvia.