Journal ArticleDOI
DNA damage in A549 cells exposed to different extracts of PM2.5 from industrial, urban and highway sites
Sa. Bonetta,Valentina Gianotti,Si. Bonetta,Fabio Gosetti,M Oddone,Maria Carla Gennaro,Elisabetta Carraro +6 more
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TLDR
In this paper, the role played by the chemical fraction of PM(2.5) in DNA damage induction in human lung cells (A549), in particular the effects of samples collected in urban, industrial and highway sites were compared.About:
This article is published in Chemosphere.The article was published on 2009-11-01. It has received 70 citations till now. The article focuses on the topics: Genotoxicity & Comet assay.read more
Citations
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Oxidative stress and inflammation generated DNA damage by exposure to air pollution particles
Peter Møller,Pernille Høgh Danielsen,Dorina Gabriela Karottki,Kim Jantzen,Martin Roursgaard,Henrik Klingberg,Ditte Marie Jensen,Daniel Vest Christophersen,Jette Gjerke Hemmingsen,Yi Cao,Steffen Loft +10 more
TL;DR: The results indicate that PM-mediated ROS production is involved in the generation of inflammation and activated inflammatory cells can increase their ROS production, indicating that air pollution particles generate oxidatively damaged DNA by promoting a milieu of oxidative stress and inflammation.
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Oxidative DNA damage and inflammatory responses in cultured human cells and in humans exposed to traffic-related particles
Udomratana Vattanasit,Panida Navasumrit,Man Bahadur Khadka,Jantamas Kanitwithayanun,Jantamas Kanitwithayanun,Jeerawan Promvijit,Herman Autrup,Mathuros Ruchirawat +7 more
TL;DR: A similar pattern of the dose-dependent responses to DEP in the lymphoblasts and lung cells suggests that circulating lymphocytes could be used as a surrogate for assessing PM-induced oxidative DNA damage and inflammatory responses in the lung.
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Gene expression profiling of A549 cells exposed to Milan PM2.5
Maurizio Gualtieri,Eleonora Longhin,Michela Mattioli,Paride Mantecca,Valentina Tinaglia,Eleonora Mangano,Maria Carla Proverbio,Giuseppina Bestetti,Marina Camatini,Cristina Battaglia +9 more
TL;DR: Winter PM2.5 is able to induce gene expression alteration, ROS production and DNA damage, likely to be related to the CYP enzyme activation in response to the polycyclic aromatic hydrocarbons adsorbed on particle surface.
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Effects of ambient PM2.5 on pathological injury, inflammation, oxidative stress, metabolic enzyme activity, and expression of c-fos and c-jun in lungs of rats.
TL;DR: In this paper, the authors showed that PM2.5 exposure induced inflammatory cell infiltration and hyperemia in the lung tissues and increased the inflammatory cell numbers in bronchoalveolar lavage fluid.
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Physicochemical and toxicological characteristics of urban aerosols during a recent Indonesian biomass burning episode
Shruti Pavagadhi,Raghu Betha,Shriram Venkatesan,Rajasekhar Balasubramanian,Manoor Prakash Hande +4 more
TL;DR: Physicochemical and toxicological characteristics of both haze and non-haze aerosols were evaluated and five PAHs known as potential or suspected carcinogens, five were found in significantly higher levels in smoke haze aerosols as compared to those in the background air.
References
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A simple technique for quantitation of low levels of DNA damage in individual cells
TL;DR: Human lymphocytes were exposed to X-irradiation or treated with H2O2 and the extent of DNA migration was measured using a single-cell microgel electrophoresis technique under alkaline conditions and this technique appears to be sensitive and useful for detecting damage and repair in single cells.
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Lung Cancer, Cardiopulmonary Mortality, and Long-term Exposure to Fine Particulate Air Pollution
C. Arden Pope,Richard T. Burnett,Michael J. Thun,Eugenia E. Calle,Daniel Krewski,Kazuhiko Ito,George D. Thurston +6 more
TL;DR: Fine particulate and sulfur oxide--related pollution were associated with all-cause, lung cancer, and cardiopulmonary mortality and long-term exposure to combustion-related fine particulate air pollution is an important environmental risk factor for cardiopULmonary and lung cancer mortality.
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Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing.
Raymond R. Tice,E. Agurell,Diana Anderson,B. Burlinson,Andreas Hartmann,H. Kobayashi,Y. Miyamae,Emilio Rojas,J.-C. Ryu,Y. F. Sasaki +9 more
TL;DR: The expert panel reached a consensus that the optimal version of the Comet assay for identifying agents with genotoxic activity was the alkaline (pH > 13) versions of the assay developed by Singh et al.
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Air pollution and health.
TL;DR: The evidence for adverse effects on health of selected air pollutants is discussed, and it is unclear whether a threshold concentration exists for particulate matter and ozone below which no effect on health is likely.
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Air Pollution and Cardiovascular Disease A Statement for Healthcare Professionals From the Expert Panel on Population and Prevention Science of the American Heart Association
Robert D. Brook,Barry A. Franklin,Wayne E. Cascio,Yuling Hong,George Howard,Michael Lipsett,Russell V. Luepker,Murray A. Mittleman,Jonathan M. Samet,Sidney C. Smith,Ira B. Tager +10 more
TL;DR: The purpose of this statement is to provide healthcare professionals and regulatory agencies with a comprehensive review of the literature on air pollution and cardiovascular disease and practical recommendations for healthcare providers and their patients are outlined.