DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139
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In this paper, a histone H2AX species that has been phosphorylated specifically at serine 139 was found to be a major component of DNA double-stranded break.About:
This article is published in Journal of Biological Chemistry.The article was published on 1998-03-06 and is currently open access. It has received 5132 citations till now. The article focuses on the topics: Chromatin & Histone H2A.read more
Citations
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Journal ArticleDOI
The DNA Damage Response: Making It Safe to Play with Knives
TL;DR: This review will focus on how the DDR controls DNA repair and the phenotypic consequences of defects in these critical regulatory functions in mammals.
Journal ArticleDOI
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
TL;DR: It is shown that ATM is held inactive in unirradiated cells as a dimer or higher-order multimer, with the kinase domain bound to a region surrounding serine 1981 that is contained within the previously described ‘FAT’ domain.
Journal ArticleDOI
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
Jirina Bartkova,Zuzana Horejsi,Karen Koed,Alwin Krämer,Frederic Tort,Karsten Zieger,Per Guldberg,Maxwell Sehested,Jahn M. Nesland,Claudia Lukas,Torben F. Ørntoft,Jiri Lukas,Jiri Bartek +12 more
TL;DR: It is shown that in clinical specimens from different stages of human tumours of the urinary bladder, breast, lung and colon, the early precursor lesions commonly express markers of an activated DNA damage response.
Journal ArticleDOI
Megabase chromatin domains involved in DNA double-strand breaks in vivo.
TL;DR: The results offer direct visual confirmation that γ-H2AX forms en masse at chromosomal sites of DNA double-strand breaks and suggest the possible existence of units of higher order chromatin structure involved in monitoring DNA integrity.
Journal ArticleDOI
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.
Tanya T. Paull,Emmy P. Rogakou,Vikky Yamazaki,Cordula U. Kirchgessner,Martin Gellert,William M. Bonner +5 more
TL;DR: The evidence presented strongly supports a role for the gamma-H2AX and the PI-3 protein kinase family in focus formation at sites of double-strand breaks and suggests the possibility of a change in chromatin structure accompanying double-Strand break repair.
References
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Crystal structure of the nucleosome core particle at 2.8 Å resolution
TL;DR: The X-ray crystal structure of the nucleosome core particle of chromatin shows in atomic detail how the histone protein octamer is assembled and how 146 base pairs of DNA are organized into a superhelix around it.
Book
DNA Repair and Mutagenesis
TL;DR: Nucleotide excision repair in mammalian cells: genes and proteins Mismatch repair The SOS response and recombinational repair in prokaryotes Mutagenesis in proKaryote Mutagenisation in eukaryotes Other DNA damage tolerance responses in eUKaryotes.
Journal ArticleDOI
A single ataxia telangiectasia gene with a product similar to pi-3 kinase
Kinneret Savitsky,Anat Bar-Shira,Shlomit Gilad,Galit Rotman,Yael Ziv,Lina Vanagaite,Danilo A. Tagle,Sara Smith,Tamar Uziel,Sharon Sfez,Maya Ashkenazi,Iris Pecker,Moshe Frydman,Reli Harnik,Sankhavaram R. Patanjali,Andrew D. Simmons,Gregory A. Clines,Adam Sartiel,Richard A. Gatti,Luciana Chessa,Ozden Sanal,Martin F. Lavin,Nicolaas G. J. Jaspers,A. Malcolm R. Taylor,Colin F. Arlett,Toru Miki,Sherman M. Weissman,Michael Lovett,Francis S. Collins,Yosef Shiloh +29 more
TL;DR: A gene, ATM, that is mutated in the autosomal recessive disorder ataxia telangiectasia was identified by positional cloning on chromosome 11q22-23 and encoded a putative protein that is similar to several yeast and mammalian phosphatidylinositol-3' kinases that are involved in mitogenic signal transduction, meiotic recombination, and cell cycle control.
Journal ArticleDOI
Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation
J. E. Brownell,J. Zhou,Tamara A. Ranalli,R. Kobayashi,Diane G. Edmondson,S. Y. Roth,C. D. Allis +6 more
TL;DR: These findings shed light on the biochemical function of the evolutionarily conserved Gcn5p-Ada complex, directly linking histone acetylation to gene activation, and indicate that histoneacetylation is a targeted phenomenon.
Journal ArticleDOI
Requirement for Ku80 in growth and immunoglobulin V(D)J recombination
André Nussenzweig,C Chen,V da Costa Soares,Mercedes Sanchez,K Sokol,Michel C. Nussenzweig,G C Li +6 more
TL;DR: The unexpected growth phenotype suggests a new and important link between Ku80 and growth control and the role of the DNA-binding subunit of DNA-PK in vivo is targeted.
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