DNA Methylation and Its Basic Function
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Cites background from "DNA Methylation and Its Basic Funct..."
...Epigenetic mechanisms of drug addictio Current Opinion in Neurobiology 2013, 23:1–8 Through deamination, glycosylation, and base excision repair, these newly discovered forms of cytosine modification can then be converted back into an unmethylated state [30,31]....
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Cites background from "DNA Methylation and Its Basic Funct..."
...Under the so-called standard model of gene expression regulation, methylation of cytosine–guanine dinucleotides (CpGs) in the promoter regions of genes has received the most attention since it is generally associated with repression of transcription, either directly, by blocking the access of transcription factors (TFs), or indirectly, by recruiting other repressive proteins with methyl-binding domains [2, 3]....
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References
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"DNA Methylation and Its Basic Funct..." refers background in this paper
...Unlike Dnmt1, both Dnmt3a and Dnmt3b when overexpressed are capable of methylating both native and synthetic DNA with no preference for hemimethylated DNA (Okano et al, 1999)....
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...Similar to Dnmt1, the knockout of Dnmt3b in mice is embryonic lethal (Okano et al, 1999)....
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...On the other hand, Dnmt3a knockout mice are runted but survive to B4 weeks after birth (Okano et al, 1999)....
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5,514 citations
"DNA Methylation and Its Basic Funct..." refers background in this paper
...For example, early-life stress in the form of maternal neglect was sufficient to alter DNA methylation in the brain of a rodent model (Weaver et al, 2004)....
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5,155 citations
"DNA Methylation and Its Basic Funct..." refers background or methods in this paper
...A few protocols are capable of distinguishing 5hmC from 5mC in the genome: CpG endlabeling followed by thin-layer chromatography (Tahiliani et al, 2009) and high-performance liquid chromatography (HPLC) with either UV detection (Liutkeviciute et al, 2009) or tandem mass spectrometry (Globisch et…...
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...Tet1 contains a DNA-binding motif similar to Ctf1, suggesting that both proteins target similar sites, in this case CpG islands, to maintain DNA demethylation (Tahiliani et al, 2009)....
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...Tet enzymes add a hydroxyl group onto the methyl group of 5mC to form 5hmC (Tahiliani et al, 2009; Ito et al, 2010)....
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...…progressively smaller tissue quantities, many of the most commonly used methods for profiling and quantification of DNA methylation, such as bisulfite sequencing and methylation-sensitive enzyme-based assays, are unable to distinguish between 5hmC and 5mC (Tahiliani et al, 2009; Huang et al, 2010)....
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4,503 citations
"DNA Methylation and Its Basic Funct..." refers background in this paper
...Of the MBD proteins, MeCP2 is the best studied in the CNS because its mutation results in Rett Syndrome, one of the most common forms of mental retardation in females (Amir et al, 1999)....
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...MBDs are more highly expressed in the brain than in any other tissue, and many MBDs are important for normal neuronal development and function (Amir et al, 1999)....
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...One of the most common forms of mental retardation, Rett Syndrome, is frequently caused by a mutation to the methyl-binding protein MeCP2 (Amir et al, 1999)....
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4,266 citations