Journal ArticleDOI
DNA methylation dynamics in health and disease
Yehudit Bergman,Howard Cedar +1 more
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TLDR
Dynamics of DNA methylation during normal development in vivo are discussed, starting from fertilization through embryogenesis and postnatal growth, as well as abnormal methylation changes that occur in cancer.Abstract:
DNA methylation is an epigenetic mark that is erased in the early embryo and then re-established at the time of implantation. In this Review, dynamics of DNA methylation during normal development in vivo are discussed, starting from fertilization through embryogenesis and postnatal growth, as well as abnormal methylation changes that occur in cancer.read more
Citations
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Journal ArticleDOI
Charting a dynamic DNA methylation landscape of the human genome
Michael J. Ziller,Hongcang Gu,Fabian Müller,Julie Donaghey,Julie Donaghey,Linus T.-Y. Tsai,Oliver Kohlbacher,Philip L. De Jager,Philip L. De Jager,Evan D. Rosen,Evan D. Rosen,David A. Bennett,Bradley E. Bernstein,Bradley E. Bernstein,Andreas Gnirke,Alexander Meissner,Alexander Meissner +16 more
TL;DR: Although in theory every CpG can change its methylation state, the results suggest that only a fraction does so as part of coordinated regulatory programs, which highlights the general inefficiency of whole-genome bisulphite sequencing.
Journal ArticleDOI
The DNA methyltransferase family: a versatile toolkit for epigenetic regulation
TL;DR: Analysis of molecular interactions and changes in gene copy numbers modulate the activity of DNMTs in diverse gene regulatory functions, including transcriptional silencing, transcriptional activation and post-transcriptional regulation by DNMT2-dependent tRNA methylation enables the DNMT family to function as a versatile toolkit for epigenetic regulation.
Journal ArticleDOI
DNA methylation and healthy human aging
TL;DR: Healthy human aging throughout the lifetime is focused on and the dynamics of DNA methylation is discussed, as well as how interactions between the genome, environment, and the epigenome influence aging rates are discussed.
Journal ArticleDOI
Identification of tissue-specific cell death using methylation patterns of circulating DNA.
Roni Lehmann-Werman,Daniel Neiman,Hai Zemmour,Joshua Moss,Judith Magenheim,Adi Vaknin-Dembinsky,Sten Rubertsson,Bengt Nellgård,Kaj Blennow,Henrik Zetterberg,Henrik Zetterberg,Kirsty L. Spalding,Michael J. Haller,Clive Wasserfall,Desmond A. Schatz,Carla J. Greenbaum,Craig Dorrell,Markus Grompe,Aviad Zick,Ayala Hubert,Myriam Maoz,Volker Fendrich,Detlef K. Bartsch,Talia Golan,Shmuel Ben Sasson,Gideon Zamir,Aharon Razin,Howard Cedar,A. M. James Shapiro,Benjamin Glaser,Ruth Shemer,Yuval Dor +31 more
TL;DR: The tissue origins of cfDNA and thus the rate of death of specific cell types can be determined in humans, offering a minimally invasive window for diagnosing and monitoring a broad spectrum of human pathologies as well as providing a better understanding of normal tissue dynamics.
Journal ArticleDOI
Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism
Samantha J. Mentch,Mahya Mehrmohamadi,Lei Huang,Xiaojing Liu,Diwakar Gupta,Dwight A.L. Mattocks,Paola Gómez Padilla,Gene P. Ables,Marcas M. Bamman,Anna E. Thalacker-Mercer,Sailendra N. Nichenametla,Jason W. Locasale +11 more
TL;DR: Modulation of methionine in diet led to changes in metabolism and histone methylation in the liver, and this dynamic interaction led to rapid changes in H3K4me3, altered gene transcription, and provided feedback regulation to one-carbon metabolism.
References
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Journal ArticleDOI
An integrated encyclopedia of DNA elements in the human genome
TL;DR: The Encyclopedia of DNA Elements project provides new insights into the organization and regulation of the authors' genes and genome, and is an expansive resource of functional annotations for biomedical research.
Journal ArticleDOI
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
TL;DR: It is demonstrated that two recently identified DNA methyltransferases, DnMT3a and Dnmt3b, are essential for de novo methylation and for mouse development and play important roles in normal development and disease.
Journal ArticleDOI
The fundamental role of epigenetic events in cancer
Peter A. Jones,Stephen B. Baylin +1 more
TL;DR: This review discusses patterns of DNA methylation and chromatin structure in neoplasia and the molecular alterations that might cause them and/or underlie altered gene expression in cancer.
Journal ArticleDOI
The epigenomics of cancer.
Peter A. Jones,Stephen B. Baylin +1 more
TL;DR: Recent advances in understanding how epigenetic alterations participate in the earliest stages of neoplasia, including stem/precursor cell contributions, are reviewed and the growing implications of these advances for strategies to control cancer are discussed.
Journal ArticleDOI
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
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