DNA Pooling: a tool for large-scale association studies
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...In human research, it is possible to carry out genome-wide association mapping by using an integrated technology package including selective genotyping, pooled DNA analysis, and microarray-based SNP genotyping with 100,000 markers (Sham et al., 2002; Meaburn et al., 2006; Yang et al., 2006)....
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...Subsequently, it has been used for linkage studies in plant...
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...This factor is then used to adjust association test statistic...
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...Higher hybridization specificity can usually be achieved in liquid phase (by using allele-specific PCR, or exonuclease assays, such as TAQMAN™ ), but as each allele is distinguished by oligonucleotides of slightly different sequence, there is the potential for alleles to be differentially amplifie...
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