DNA released from dying host cells mediates aluminum adjuvant activity
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1,357 citations
Cites background from "DNA released from dying host cells ..."
...The release of DNA from dying host cells has been shown to stimulate adaptive immune responses in theTBK1-IRF3-type I IFN-dependentmanner, leading to alum adjuvant activity (Marichal et al., 2011)....
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1,199 citations
Cites background from "DNA released from dying host cells ..."
...It has been suggested that endogenous adjuvants released from dying cells are capable of initiating innate immune cell activation (Jounai et al., 2012; Kono and Rock, 2008; Marichal et al., 2011; McKee et al., 2013)....
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"DNA released from dying host cells ..." refers background in this paper
...Because released host cell DNA may trigger immune response...
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6,188 citations
Additional excerpts
...Tbk1/Tnf DKO, Tlr9 −/− and Zbp1 −/− mice have been described elsewher...
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2,625 citations
"DNA released from dying host cells ..." refers background in this paper
...through inflammasomes containing the cytosolic receptor Nlrp3 (NLR family, pyrin domain containing 3...
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2,481 citations