DNA-replication checkpoint control at the Drosophila midblastula transition
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...In addition, a Drosophila Chk1 homolog, Grapes, modulates cell cycle timing at the midblastula transition during embryogenesis (Sibon et al. 1997)....
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...This idea is supported by the fact that the Drosophila Chk1 mutant, Grapes (Sibon et al. 1997), and the ATR homolog, Mei-41, mutant (Sibon et al. 1999) die at the midblastula transition, showing a defect in DNA replication checkpoint function....
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...Likewise, the Drosophila Chk1 homolog Grapes is required for the replication checkpoint in early embryos (Fogarty et al. 1997; Sibon et al. 1997)....
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...Studies in yeast and vertebrates indicate that the Cdc2–cyclin complex is activated by the Cdc25 phosphatase, which removes the inhibitory tyrosine phosphates and thus drives the cell into mitosi...
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...The switch to zygotic control of embryogenesis at the midblastula transition is accompanied by significant increases in cell-cycle length and gene transcription, and changes in embryo morpholog...
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