Does the microbiota play a role in the pathogenesis of autoimmune diseases
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TLDR
This review summarises the current status on the role of the microbiota in autoimmune diseases and offers novel insight into factors that initiate and drive disease progression, stratify patient risk for complications and ultimately deliver new therapeutic strategies.Abstract:
The microbiota of the human metaorganism is not a mere bystander. These microbes have coevolved with us and are pivotal to normal development and homoeostasis. Dysbiosis of the GI microbiota is associated with many disease susceptibilities, including obesity, malignancy, liver disease and GI pathology such as IBD. It is clear that there is direct and indirect crosstalk between this microbial community and host immune response. However, the precise mechanism of this microbial influence in disease pathogenesis remains elusive and is now a major research focus. There is emerging literature on the role of the microbiota in the pathogenesis of autoimmune disease, with clear and increasing evidence that changes in the microbiota are associated with some of these diseases. Examples include type 1 diabetes, coeliac disease and rheumatoid arthritis, and these contribute significantly to global morbidity and mortality. Understanding the role of the microbiota in autoimmune diseases may offer novel insight into factors that initiate and drive disease progression, stratify patient risk for complications and ultimately deliver new therapeutic strategies. This review summarises the current status on the role of the microbiota in autoimmune diseases.read more
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Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis
Kosuke Mima,Reiko Nishihara,Zhi Rong Qian,Yin Cao,Yasutaka Sukawa,Jonathan A. Nowak,Juhong Yang,Juhong Yang,Ruoxu Dou,Yohei Masugi,Mingyang Song,Aleksandar Kostic,Aleksandar Kostic,Marios Giannakis,Marios Giannakis,Marios Giannakis,Susan Bullman,Susan Bullman,Danny A. Milner,Danny A. Milner,Hideo Baba,Edward Giovannucci,Edward Giovannucci,Levi A. Garraway,Levi A. Garraway,Levi A. Garraway,Gordon J. Freeman,Gordon J. Freeman,Glenn Dranoff,Glenn Dranoff,Wendy S. Garrett,Wendy S. Garrett,Curtis Huttenhower,Curtis Huttenhower,Matthew Meyerson,Matthew Meyerson,Matthew Meyerson,Jeffrey A. Meyerhardt,Andrew T. Chan,Andrew T. Chan,Charles S. Fuchs,Charles S. Fuchs,Shuji Ogino,Shuji Ogino +43 more
TL;DR: The amount of F. nucleatum DNA in colorectal cancer tissue is associated with shorter survival, and may potentially serve as a prognostic biomarker, which may have implications in developing cancer prevention and treatment strategies through targeting GI microflora by diet, probiotics and antibiotics.
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Current Understanding of Dysbiosis in Disease in Human and Animal Models.
TL;DR: This review article has focused on explaining the multiple types of dysbiosis, as well as Dysbiosis-related diseases and potential treatments to apply this knowledge to understand a possible cause and potentially find therapeutic strategies for IBD aswell as the other dysbiotic- related diseases.
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TL;DR: This review will highlight the evidence by which stress and the gut microbiota interact in the regulation of visceral nociception and the mechanisms by which microbiota can affect the stress response and behavioral outcomes with an emphasis on visceral pain.
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TL;DR: The Human Microbiome Project Consortium reported the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome as discussed by the authors.
Journal Article
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TL;DR: The need to consider the microbiome when evaluating human development, nutritional needs, physiological variations and the impact of westernization is underscored, as distinctive features of the functional maturation of the gut microbiome are evident in early infancy as well as adulthood.
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Peter J. Turnbaugh,Ruth E. Ley,Micah Hamady,Claire M. Fraser-Liggett,Rob Knight,Jeffrey I. Gordon +5 more
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Iain B. McInnes,Georg Schett +1 more
TL;DR: The increased understanding of the immune mechanisms of rheumatoid arthritis has led to the development of a considerable number of new therapeutic agents that alter the natural history of the disease and reduce mortality.
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