Dogs are more permissive than cats or guinea pigs to experimental infection with a human isolate of Bartonella rochalimae.
Bruno B Chomel,Jennifer B. Henn,Rickie W. Kasten,Nathan C. Nieto,Janet E Foley,Sophia Papageorgiou,Claire Allen,Jane E. Koehler +7 more
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It is suggested that dogs could be a reservoir of this strain of B. rochalimae, in contrast to cats and guinea pigs, that was first isolated from the blood of a human who traveled to Peru and was exposed to multiple insect bites.Abstract:
Bartonella rochalimae was first isolated from the blood of a human who traveled to Peru and was exposed to multiple insect bites. Foxes and dogs are likely natural reservoirs for this bacterium. We report the results of experimental inoculation of two dogs, five cats and six guinea pigs with the only human isolate of this new Bartonella species. Both dogs became bacteremic for 5-7 weeks, with a peak of 10 3 -10 4 colony forming units (CFU)/mL blood. Three cats had low bacteremia levels (< 200 CFU/mL) of 6-8 weeks' duration. One cat that remained seronegative had two bacterial colonies isolated at a single culture time point. A fifth cat never became bacteremic, but seroconverted. None of the guinea pigs became bacteremic, but five seroconverted. These results suggest that dogs could be a reservoir of this strain of B. rochalimae, in contrast to cats and guinea pigs. Bartonella rochalimae / dogs / cats / guinea pigs / zoonosisread more
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Intruders below the Radar: Molecular Pathogenesis of Bartonella spp.
Alexander Harms,Christoph Dehio +1 more
TL;DR: Current knowledge on the molecular processes underlying both the infection strategy and pathogenesis of Bartonella are compiled and their connection to the clinical presentation of human patients is discussed, which ranges from minor complaints to life-threatening disease.
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The Trw Type IV Secretion System of Bartonella Mediates Host-Specific Adhesion to Erythrocytes
Muriel Vayssier-Taussat,Danielle Le Rhun,Hong Kuan Deng,Francis Biville,Sandra Cescau,Antoine Danchin,Geneviève Marignac,Evelyne Lenaour,Henri Jean Boulouis,Maria Mavris,Lionel Arnaud,Huanming Yang,Jing Wang,Maxime Québatte,Philipp Engel,Henri L Saenz,Christoph Dehio +16 more
TL;DR: It is shown that the laterally acquired Trw T4SS diversified in the Bartonella lineage to facilitate host-restricted adhesion to erythrocytes in a wide range of mammals.
Journal ArticleDOI
Parallel Evolution of a Type IV Secretion System in Radiating Lineages of the Host-Restricted Bacterial Pathogen Bartonella
Philipp Engel,Walter Salzburger,Marius Liesch,Chao-Chin Chang,Soichi Maruyama,Christa Lanz,Alexandra Calteau,Aurélie Lajus,Claudine Médigue,Stephan C. Schuster,Christoph Dehio +10 more
TL;DR: The parallel molecular evolution of the VirB/Bep system displays a striking example of a key innovation involved in independent adaptive processes and the emergence of bacterial pathogens, highlighting the remarkable evolvability of T4SSs and their effector proteins, explaining their broad application in bacterial interactions with the environment.
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Persistence of Bartonella spp. stealth pathogens: from subclinical infections to vasoproliferative tumor formation
TL;DR: The ability of Bartonella spp.
Journal ArticleDOI
Bartonella infections in cats and dogs including zoonotic aspects
TL;DR: An update and European perspective on Bartonella infections in cats and dogs, including clinical, diagnostic, epidemiological, pathological, treatment and zoonotic aspects is provided.
References
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Bartonella Spp. in Pets and Effect on Human Health
TL;DR: Pets represent a large reservoir for human infection and can be a source of infection for humans and animals alike.
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Endocarditis in a dog due to infection with a novel Bartonella subspecies.
Edward B. Breitschwerdt,Dorsey L. Kordick,David E. Malarkey,Bruce W. Keene,Ted L. Hadfield,Kenneth H. Wilson +5 more
TL;DR: P phenotypic and genotypic characterization of the isolate indicated that this organism, which can induce endocarditis in dogs, is a novel Bartonella subspecies containing an insertion sequence unique among currently recognized Bart onella species.
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Bacteremia, fever, and splenomegaly caused by a newly recognized bartonella species.
Marina E. Eremeeva,Helen L. Gerns,Shari L. Lydy,Jeanna S. Goo,Edward T. Ryan,Smitha S. Mathew,Mary Jane Ferraro,Judith M. Holden,William L. Nicholson,Gregory A. Dasch,Jane E. Koehler +10 more
TL;DR: A patient who had fever and splenomegaly after traveling to Peru and also had bacteremia from an organism that resembled Bartonella bacilliformis was described, which revealed that this fastidious bacterium represented a previously uncultured and unnamed bartonella species.
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Experimental and natural infection with Bartonella henselae in domestic cats
Rachel C. Abbott,Bruno B Chomel,Rickie W. Kasten,Kim A. Floyd-Hawkins,Yoko Kikuchi,Jane E. Koehler,Niels C Pedersen +6 more
TL;DR: These studies indicate that B. henselae exists in an almost perfect host-parasite relationship with its feline host, but that most cats can ultimately rid themselves of the infection.
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Surveillance of Egyptian fleas for agents of public health significance: Anaplasma, Bartonella, Coxiella, Ehrlichia, Rickettsia, and Yersinia pestis.
Amanda D. Loftis,Will K. Reeves,Daniel E. Szumlas,Magda M. Abbassy,Ibrahim M. Helmy,John R. Moriarity,Gregory A. Dasch +6 more
TL;DR: Serologic surveys in Egypt have documented human and animal exposure to vector-borne bacterial pathogens, but the presence and distribution of these agents in arthropods has not been determined and fleas were collected from mammals trapped in 17 cities throughout Egypt.