Journal ArticleDOI
Domino-reactions: The tandem-knoevenagel-hetero-diels-alder reaction and its application in natural product synthesis
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This article is published in Journal of Heterocyclic Chemistry.The article was published on 1990-01-01. It has received 176 citations till now. The article focuses on the topics: Knoevenagel condensation & Diels–Alder reaction.read more
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Domino Reactions in Organic Synthesis
TL;DR: It is shown that domino reactions initiated by oxidation or reduction or reduction, as well as other mechanisms, can be inhibited by various materials, such as Na6(CO3)(SO4), Na2SO4, Na2CO3, and so on.
Journal ArticleDOI
Benign by design: catalyst-free in-water, on-water green chemical methodologies in organic synthesis
TL;DR: Various named reactions, multi-component reactions and the synthesis of heterocyclic compounds are discussed including the use of various energy input systems such as microwave- and ultrasound irradiation, among others.
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Utilisation of 1,3‐Dicarbonyl Derivatives in Multicomponent Reactions
TL;DR: In this article, an overview of the potential of 1,3-dicarbonyl derivatives for the selective construction of highly functionalised small organic molecules of high synthetic and biological value is presented.
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Multicomponent domino reactions for the synthesis of biologically active natural products and drugs.
Lutz F. Tietze,Andrea Modi +1 more
TL;DR: The synthesis of the enantiopure alkaloid (−)‐hirsutine 22, which has a strong inhibitorial effect on influenza A viruses, was accomplished using a biomimetic domino Knoevenagel‐hetero‐Diels Alder‐solvolysis‐hydrogenation process.
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Sequentielle Transformationen in der Organischen Chemie eine Synthesestrategie mit Zukunft
Lutz F. Tietze,Uwe Beifuss +1 more
TL;DR: The organisch-chemische Synthese hat stets eine grose Faszination auf den Chemiker ausgeubt, und sie wird auch in Zukunft nichts von ihrer Bedeutung verlieren as discussed by the authors.
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Mechanistic Aspects of Diels‐Alder Reactions: A Critical Survey
Jürgen Sauer,Reiner Sustmann +1 more
TL;DR: In this paper, a line of distinction between the mechanistic alternatives for the Diels-Alder reaction was drawn, considering all experimental and theoretical criteria, for one-step and two-step reactions.
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Activated Dimethyl Sulfoxide: Useful Reagents for Synthesis
Anthony J. Mancuso,Daniel Swern +1 more