Donor Leukocyte Transfusions for Treatment of Recurrent Chronic Myelogenous Leukemia in Marrow Transplant Patients
Hans-Jochem Kolb,J. Mittermüller,Ch. Clemm,Ernst Holler,Georg Ledderose,G. Brehm,M.U. Heim,Wolfgang Wilmanns +7 more
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TLDR
Three patients with hematologic relapse after bone marrow transplantation for chronic myelogenous leukemia were treated with interferon alpha and transfusion of viable donor buffy coat and had complete hematological and cytogenetic remission, which persisted 32 to 91 weeks after treatment, an example of adoptive immunotherapy without cytoreductive chemotherapy or radiotherapy in human chimeras.About:
This article is published in Blood.The article was published on 1990-12-15 and is currently open access. It has received 1419 citations till now. The article focuses on the topics: Donor lymphocyte infusion & Myelogenous.read more
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Graft-Versus-Leukemia Effect of Donor Lymphocyte Transfusions in Marrow Grafted Patients
Hans-Jochem Kolb,A Schattenberg,JM Goldman,B Hertenstein,N Jacobsen,W Arcese,P Ljungman,A Ferrant,L Verdonck,D Niederwieser +9 more
TL;DR: Donor lymphocyte transfusions exert strong effects against myeloid forms of leukemia and induce durable remissions in CML.
Journal ArticleDOI
Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T Cell Transfer Immunotherapy
Steven A. Rosenberg,James Chih-Hsin Yang,Richard M. Sherry,Udai S. Kammula,Michael S. Hughes,Giao Q. Phan,Deborah Citrin,Nicholas P. Restifo,Paul F. Robbins,John R. Wunderlich,Kathleen E. Morton,Carolyn M. Laurencot,Seth M. Steinberg,Donald E. White,Mark E. Dudley +14 more
TL;DR: Cell transfer therapy with autologous TILs can mediate durable complete responses in patients with metastatic melanoma and has similar efficacy irrespective of prior treatment.
Journal ArticleDOI
Chronic myeloid leukemia.
TL;DR: This work has demonstrated that CML can be curable through immune-mediated elimination of leukemia cells by allogeneic T lymphocytes, and specific inhibition of signal transduction by the tyrosine kinase Bcr-Abl has been found to be active in managing the disease.
Journal ArticleDOI
Adoptive cell transfer: a clinical path to effective cancer immunotherapy
Steven A. Rosenberg,Nicholas P. Restifo,James Chih-Hsin Yang,Richard A. Morgan,Mark E. Dudley +4 more
TL;DR: The ability to genetically engineer human lymphocytes and use them to mediate cancer regression in patients has opened possibilities for the extension of ACT immunotherapy to patients with a wide variety of cancer types and is a promising new approach to cancer treatment.
Journal ArticleDOI
Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects
Peter A. McSweeney,Peter A. McSweeney,Peter A. McSweeney,Dietger Niederwieser,Dietger Niederwieser,Dietger Niederwieser,Judith A. Shizuru,Judith A. Shizuru,Judith A. Shizuru,Brenda M. Sandmaier,Brenda M. Sandmaier,Brenda M. Sandmaier,Arthur J. Molina,Arthur J. Molina,Arthur J. Molina,David G. Maloney,David G. Maloney,David G. Maloney,Thomas R. Chauncey,Thomas R. Chauncey,Thomas R. Chauncey,Ted Gooley,Ted Gooley,Ted Gooley,U Hegenbart,U Hegenbart,U Hegenbart,Richard A. Nash,Richard A. Nash,Richard A. Nash,Jerald P. Radich,Jerald P. Radich,Jerald P. Radich,John L. Wagner,John L. Wagner,John L. Wagner,Steven Minor,Steven Minor,Steven Minor,Frederick R. Appelbaum,Frederick R. Appelbaum,Frederick R. Appelbaum,William I. Bensinger,William I. Bensinger,William I. Bensinger,Eileen Bryant,Eileen Bryant,Eileen Bryant,Mary E.D. Flowers,Mary E.D. Flowers,Mary E.D. Flowers,George E. Georges,George E. Georges,George E. Georges,F. Carl Grumet,F. Carl Grumet,F. Carl Grumet,Hans-Peter Kiem,Hans-Peter Kiem,Hans-Peter Kiem,Beverly Torok-Storb,Beverly Torok-Storb,Beverly Torok-Storb,Cong Yu,Cong Yu,Cong Yu,Karl G. Blume,Karl G. Blume,Karl G. Blume,Rainer Storb,Rainer Storb,Rainer Storb +71 more
TL;DR: A novel allografting approach, based on the use of postgrafting immunosuppression to control graft rejection and GVHD, has dramatically reduced the acute toxicities of allogRAFTing.
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