Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease
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...Recent research has moved the stem cell field closer to that goal through development of strategies to generate cells that would otherwise be difficult to obtain, like neurons or cardiomyocytes (Kriks et al., 2011; Shiba et al., 2012; Son et al., 2011)....
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1,526 citations
Cites methods from "Dopamine neurons derived from human..."
...Building upon a 2D differentiation protocol for generating midbrain dopaminergic (DA) neurons (Kriks et al., 2011), we applied Sonic hedgehog (SHH) agonists (recombinant SHH and Purmorphamine), FGF-8, SMAD inhibitors (SB431542 and LDN193189), and GSK3b inhibitor (CHIR99021) to induce floor-plate differentiation of human iPSCs, which were transferred to SpinU at day 14 (Figure 6A)....
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...Building upon a 2D differentiation protocol for generating midbrain dopaminergic (DA) neurons (Kriks et al., 2011), we applied Sonic Hedgehog (SHH) agonists (recombinant SHH and Purmorphamine), FGF-8, SMAD inhibitors (SB431542 and LDN193189), and GSK3β inhibitor (CHIR99021) to induce floor plate…...
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1,111 citations
Cites background from "Dopamine neurons derived from human..."
...…to examine specific subtypes of neurons, to generate human neurons for regenerative medicine, and to investigate changes in human neurons in neuropsychiatric disorders (e.g., see Cho et al., 2008; Fasano et al., 2010; Kriks et al., 2011; Shi et al., 2012; Chambers et al., 2012; Ma et al., 2012)....
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...from Human Pluripotent Stem Cells...
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...Kriks et al., 2011 22056989 NPCs 4 weeks ND ND 40–70...
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"Dopamine neurons derived from human..." refers methods in this paper
...Primates: two adult (17–18 year old; 10–12 kg; female) rhesus monkeys were rendered hemiparkinsonian via carotid MPTP administration followed by weekly intravenous MPTP administration to create a bilateral parkinsonian syndrom...
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